whalestales, ASN, RN 302 Posts Specializes in Emergency. Jan 30, 2021 Pfizer #1 12/17 - Soreness in my arm for 2 days Pfizer #2 1/7 - Soreness for 2 days, about 12 hours after the shot I had fever, chills and a headache. I took an acetaminophen and went to bed. Symptoms were gone by the time I woke up the next morning other than the soreness. I normally get a welt that lasts about a week with vaccines so this was actually much better than normal!