Published
The manufacturer does not recommend mixing, so I'd stick with that. However, some research is being done that might suggest other possibilities for the future.
While Sanofi-Aventis says that Lantus should not be mixed with other insulins, two recent studies published indicate that mixing Lantus with a short-acting insulin analog and injecting immediately has no adverse effect on blood sugar control. The two studies are:
- Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitus (J Pediatr. 2006 Apr;148(4):481-4.)
- Effects of Mixing Glargine and Short-Acting Insulin Analogs on Glucose Control (PDF)
If you decide to mix Lantus, be sure to tell your diabetes team. Note that mixing is off-label use.
http://www.childrenwithdiabetes.com/d_0n_115.htm
Until there are official guidelines to offer protection of patient and practitioner, I would stick with the manufacturer's prohibition of mixing Lantus with anything else.
wonderbee, BSN, RN
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Can lantus and lispro be mixed?