Maybe not afflictions per se, but these scenarios came to mind:
Fred Flintstone as a neurosurgeon?
Barney Rubble as his anesthesiologist?
Huey, Dewey and Louis as experimental lab subjects; one gets the new med being tested, one gets the placebo, one receives no tx. at all.
Baby Huey -- metabloic (sin-drone) syndrome plus autism and optimism.
Lucy and Tubby and Alvin -- diagnoses open to suggestion; very odd trio.* / *Witness 3 pages of cartoon panels in which one or the other of them are saying a funny word, repeating it over and over and over, ("purple-purple-purple-purple-purple-purple"...etc) until it has no meaning but is only a sound of syllables run together and they can't catch their breath at the silly blubberings their mouth is going through trying to say the word faster and faster.
-Jeeves and Maggie -close encounters of the 1920's kind.
I can't think of any more right now , I'm trying to watch a movie