zofran question

i infuse zofran over 15 min, quite often.

many of my hospice pts use this route.

leslie

HI!

It said: gtt, meaning drops? I though Zofran could only be administered IV or IM, but I could be wrong. IV/IM are the only two routes that I have ever administered it.

Did you get it figured out?

If it said "Zofran gtt" it would be likely talking about a zofran drip rather than zofran drops. A zofran drip would be totally worthless in my opinion (unless if the MAR reflects that it's given IVBP over 10-15 minutes).

I've seen it given as a continuous infusion.

I have only given it IVP. I learned in nursing school that it is NOT compatible with LR by the way. RN on the floor gave it through the same line and it precipitated.

Thanks guys this was a continuous infusion-odd. Thanks again for the info CAT

Used as a 15 minute premedication IVPB in chemo patients.

I have never seen it as continuous.....

I've worked onc forever,I've never seen it as a gtt

I've worked onc forever,I've never seen it as a gtt

This was back when it first came out. Premed, then a continuous infusion after the chemo. Our docs played with this for a while, but it didn't seem to be any more effective.

Pharmacokinetics: Pharmacokinetic studies in human volunteers showed peak plasma levels of 20 to 30 ng/mL at around 1 1/2 hours after an 8 mg oral dose of ondansetron. An 8 mg infusion of ondansetron reached peak plasma levels of 80 to 100 ng/mL. Repeat dosing of an 8 mg tablet every 8 hours for 6 days increased the peak plasma value to 40 ng/mL. A continuous i.v. infusion of 1 mg/hour after the initial 8 mg loading dose of ondansetron maintained plasma levels over 30 ng/mL during the following 24 hour period.

------

Initial Dose: 8 mg infused i.v. over 15 minutes given 30 minutes prior to chemotherapy; or 8 mg infused i.v. over 15 minutes, given 30 minutes prior to chemotherapy, followed by 1 mg/h by continuous infusion for up to 24 hours; or 32 mg diluted in 50 to 100 mL of saline or other compatible infusion fluid and infused over not less than 15 minutes**, given 30 minutes prior to chemotherapy.

**No significant differences in terms of emesis control or grade of nausea have been demonstrated between the 32 mg single dose, the 8 mg single dose, or the 8 mg dose followed by the 24 hour 1 mg/hour continuous infusion.**

http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20Z)/ZOFRAN.html

I have given Zofran PO and Zofran IVP, but never IM. I have never heard of a drip, but guess it isn't impossible.

I don't know about zofran drips, but they also have zofran pumps -mainly used in patients with severe hyperemesis gravidarum that does not respond to traditional treatment. I believe it is similar to how an insulin pump works.