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D5W vs. D5 NS

Medications   (284,452 Views 14 Comments)
by LucyLu LucyLu (New Member) New Member

1,720 Visitors; 9 Posts

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Can someone explain the difference between D5W and D5NS. THANKS...:uhoh3:

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NurseyPoo has 3 years experience and works as a RN - ICU.

4,274 Visitors; 154 Posts

D5W (260 mOsm/L) = Isotonic Solution: Osmolarity about equal to serum, expands intravascular compartment.

D5 NS (560 mOsm/L) = Hypertonic Solution: Osmolarity higher than serum, draws fluid into the intravascular compartment from cells and interstitial compartments.

I hope this helps:spin: ;) :spin:

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AnnieOaklyRN works as a RN, Paramedic.

1 Follower; 33,734 Visitors; 2,577 Posts

D5W is 5% dextrose in water is hypotonic so it moves fluid into the cells out of the circulation.

D5NS is 5% dextrose in normal saline. Is hypertonic so it does the opposite, it moves fluid out of the cells and into the circulation.

Hope this helps

Sweetooth

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AnnieOaklyRN works as a RN, Paramedic.

1 Follower; 33,734 Visitors; 2,577 Posts

I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.

Swtooth

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1,720 Visitors; 9 Posts

Yes, thanks that helps.

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West_Coast_Ken has 5 years experience and works as a RN.

2,505 Visitors; 214 Posts

I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.

I just want to add to what swtooth said: the reason isotonic D5W becomes hypotonic in the body is because the glucose is broken down once it is in the body by insulin so this is not an immediate change but it does happen quickly.

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NRSKarenRN has 40 years experience as a BSN and works as a Registered Nurse, Home Health.

5 Followers; 9 Articles; 159,355 Visitors; 14,398 Posts

Check out: A Closer Look at IV Fluids

Edited by sirI

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Roy Fokker is a BSN, RN and works as a Emergency Department.

1 Follower; 2 Articles; 32,234 Visitors; 2,010 Posts

Very good website!

Edited by sirI

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RNsRWe works as a Registered Nurse.

3 Articles; 88,877 Visitors; 10,428 Posts

I copied this info, as I'm often wondering why I'm hanging this fluid instead of that one; it's not something we were taught in detail and obviously on med-surg I'm ALWAYS hanging fluids.

However, the article said to look to "What's in There? Contents of Some Common I.V. Fluids" for some more info, but I can't find how to get this other article....?

I'd love to have a breakdown for some other fluids, such as Lactated Ringers. Patients often ask "what's that for" and beyond giving them a very basic "it keeps you hydrated" response, it'd be nice to know for myself a bit more!

Edited by sirI

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1,877 Visitors; 19 Posts

Super helpful all you smart nurses!

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turnforthenurse has 7 years experience and works as a ER nurse.

36,156 Visitors; 3,364 Posts

I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.

Swtooth

This is because once D5W is in the body, the dextrose is metabolized and you are left with free water, which is hypotonic.

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