D5W vs. D5 NS

  1. Can someone explain the difference between D5W and D5NS. THANKS...
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  2. 13 Comments

  3. by   NurseyPoo
    D5W (260 mOsm/L) = Isotonic Solution: Osmolarity about equal to serum, expands intravascular compartment.

    D5 NS (560 mOsm/L) = Hypertonic Solution: Osmolarity higher than serum, draws fluid into the intravascular compartment from cells and interstitial compartments.

    I hope this helps:spin: :spin:
  4. by   AnnieOaklyRN
    D5W is 5% dextrose in water is hypotonic so it moves fluid into the cells out of the circulation.

    D5NS is 5% dextrose in normal saline. Is hypertonic so it does the opposite, it moves fluid out of the cells and into the circulation.

    Hope this helps


    Sweetooth
  5. by   AnnieOaklyRN
    I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.

    Swtooth
  6. by   LucyLu
    Yes, thanks that helps.
  7. by   West_Coast_Ken
    Quote from swtooth
    I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.
    I just want to add to what swtooth said: the reason isotonic D5W becomes hypotonic in the body is because the glucose is broken down once it is in the body by insulin so this is not an immediate change but it does happen quickly.
  8. by   NRSKarenRN
    Last edit by sirI on Jan 30, '12
  9. by   Roy Fokker
    Very good website!
    Last edit by sirI on Jan 30, '12
  10. by   RNsRWe
    I copied this info, as I'm often wondering why I'm hanging this fluid instead of that one; it's not something we were taught in detail and obviously on med-surg I'm ALWAYS hanging fluids.

    However, the article said to look to "What's in There? Contents of Some Common I.V. Fluids" for some more info, but I can't find how to get this other article....?

    I'd love to have a breakdown for some other fluids, such as Lactated Ringers. Patients often ask "what's that for" and beyond giving them a very basic "it keeps you hydrated" response, it'd be nice to know for myself a bit more!
    Last edit by sirI on Jan 30, '12
  11. by   Friendli
    Super helpful all you smart nurses!
  12. by   turnforthenurse
    Quote from HappyParamedicRN
    I just want to add to what nursey poo said. D5W is technically isotonic, but it becomes hypotonic once in the body so it pulls fluid out of the vasculature and into the cells.

    Swtooth
    This is because once D5W is in the body, the dextrose is metabolized and you are left with free water, which is hypotonic.
  13. by   Robublind
  14. by   sirI
    Link repaired.

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