Prednisone

What has your research revealed to you?

thread moved for best response

My research turned up nothing. That's why I'm here.

I could be wrong... but I've never seen prednisone pushed. Only methylprednisolone. (Solu-Medrol). And I've never, ever heard of this side effect of IV glucocorticoids.

Prednisone is only available in pill form in the US. Prednisolone is liquid(oral).

Where did you get the information for your initial query? I googled and only found an obscure reference (but to rapid IVP of dexamethasone not prednisone) on WebMD buried in another article. I found nothing in any of the six drug references I have access to.

I also looked this up earlier today bc I thought it was so obscure and couldn't find anything about it.

Lol then I wondered if we were all being tricked and now there's nurses across the country googling about steroids and genital itching. :)

I'm not sure how you would expect to "quickly push" a PO med so therefore genital itching/burning from an IV push would not be possible. The IV form of this med is methylprednisolone and I believe should be pushed over 15 mins or something to that affect (have only done a brief overview of this med and I don't have the desire to look it up). I believe that over time, this drug can have a side effect of lady partsl itching or burning, but have not been instructed to not push quickly for risk of this side affect. I am actually more curious as to what brought this question on, then I am about the actual answer. If there is in fact an answer at all.

Dexamethasone IV can cause it.

Please note that all corticosteroid-related drugs are not "prednisone." Yes, it matters. Prednisone per se (meaning, itself) is an oral drug.

I have had patients tell me about that with Solu-Medrol (methylprednisolone) and Decadron (dexamethasone). Some have been more couth about it than others :) but they all describe the same thing-- creepy-crawlies in the scrotum. I can't imagine what the mechanism is, but since I haven't pushed the stuff in 25 years and they still don't know, I'm guessing nobody much cares enough to research it.

The lady partsl itching and burning with longterm use is more likely to be related to increased lady partsl yeast infections from the changes in blood sugar and immunosuppression that can happen c longterm corticosteroids. I don't think it's related to the scrotal symptoms c push admin.

Just speaking from experience…I pushed dexamethasone too quickly once. Right after pushing, the pt moaned, said something to the effect of "holy poo" and described and intense burning in the genital/anal region (I forget her exact words for the anatomy, but I'm sure I can't post it here). Apparently other the other ER nurses about this reaction…it seems to be well known. I have no idea of the mechanism, but now I always put my dexamethasone in a 50 mL bag of NSS and piggyback it in. I always do a (fairly) flow push of methylprednisolone and have never seen such a reaction.

That's good to know Esme, and GrnTea. I learn IVs and get more pharm next semester. I would of course research any drugs I give before giving them, but it will be good to keep this in mind about IV steroids.

Just speaking from experience…I pushed dexamethasone too quickly once. Right after pushing, the pt moaned, said something to the effect of "holy poo" and described and intense burning in the genital/anal region (I forget her exact words for the anatomy, but I'm sure I can't post it here). Apparently other the other ER nurses about this reaction…it seems to be well known. I have no idea of the mechanism, but now I always put my dexamethasone in a 50 mL bag of NSS and piggyback it in. I always do a (fairly) flow push of methylprednisolone and have never seen such a reaction.

Thanks for not getting into the semantic nit-picking about Owlieo.Os use of the drug name "prednisone" when it was obvious the meaning was I.V. corticosteroid. I haven't see this reaction and will be on the lookout for it in the future;(and I've been in acute care for 30 years). I recently changed from an area where I almost never gave IV corticosteroids to one where I give them once a week or so. Does anyone know if it occurs with both Solu-Medrol and Solu-Cortef? Thanks to OwlieO.O for posting about this.