Case Study: An OB Catastrophe

The following is a case simulation involving a patient initially encountered in Labor and Delivery. While the initial encounter occurred in a specific setting, this particular case will evolve and include transitions to various specialty areas over the healthcare continuum. Specialties Critical Case Study

Updated:  

Case Study Objectives

  1. Present a simulated case as it evolves over time.
  2. Encourage open discussion from nurses that represent a variety of specialties.
  3. Promote learning based on the:
    • details of the case
    • evaluation of the data
    • known interventions in order to provide holistic care
  4. Recognize maternal morbidity and mortality as a serious public health issue facing the world.

Introduction

The initial presentation that will proceed is meant to set the tone for the next set of events that will occur. I would like to preface by saying that this particular part of the case is where I have no actual nursing experience so I encourage colleagues who work in this specialty area to chime in with their responses.

Let's keep this lively, but also make sure we are respectful of each other.  Remember that we work in different hospitals and protocols may be different.  Also, be aware that while the following scenario seems "garden variety", it will get more "exciting" as we move along.

Case Specifics

History / Presentation

EJ is a 32-year old, Gravida 4 Para 2, at 34 weeks and 2 days gestational age. She has no chronic medical problems but admits to current tobacco smoking since age 17.  She says that she has been trying to quit and has cut back her smoking to 2-3 cigarettes a day.  She lives with her husband and two children ages 3 and 5 in a 2-bedroom apartment. 

She receives prenatal care at an urban Federally Qualified Healthcare Center (FQHC).  She previously worked as a server at a restaurant but has become unemployed for a couple of months due to restaurant closures from the coronavirus pandemic.  She has good family support from her parents and her husband, RJ, who is a delivery truck driver.  She is insured through her husband's coverage. 

Today, she called her Women's Health Nurse Practitioner (WHNP) when she experienced a gush of watery fluid from her lady parts while playing with her children.  She was told to come to OB Triage at the nearby Tertiary Medical Center Antepartum Unit.  Upon presentation, she was seen by the OB Triage nurse who found her anxious but well-appearing. 

Vital Signs

  • Temperature: 36.7 degrees C
  • Heart Rate: 84
  • Respiratory Rate: 16
  • Blood Pressure: 112/74
  • O2 Saturation: 96% RA
  • Fetal Heart Rate (FHR): 140

Physical / Pelvic Examination

An OB-Gyn resident saw EJ and performed a physical examination that revealed clear, pale yellow, odorless fluid leaking out of her endocervical canal with pooling in the lady partsl vault.

Diagnostic Studies

The OB-Gyn resident performed ultrasonography which revealed:

  • oligohydramnios
  • a fetus that is small for its age, without birth defects, in no distress
  • a placenta that does not cover the cervix

Recommendation

The OB-Gyn team recommended admission to the Antepartum Unit.

Diagnosis

At this point, EJ's diagnosis seems obvious but you are welcome to state it in your response to the thread.

1 - As EJ's nurse, state some assessment findings that would make you concerned. 

2 - As the nurse in that unit, what laboratory tests and monitoring procedures would you anticipate in this case, and why?

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Recap of previous events

Now that we've all been acquainted with EJ's case, let's summarize what the data revealed to us and start with her diagnosis at this point.  Kudos to @klone for mentioning the diagnosis in her response which is: Preterm Prelabor Rupture of Membranes (PPROM).  Peterm because the event happened before 37 weeks and Prelabor because it occurred before onset of uterine contractions.  PPROM occurs in up to 3% of pregnancies (1) and the etiology is not well understood.  A history of previous PPROM, genital tract infection, and cigarette smoking have been implicated as risk factors (2).

The classic presentation of PPROM were present in EJ: "gush of clear or pale yellow fluid from the lady parts".  Direct observation of amniotic fluid leaking from the cervical os and pooling in the lady parts vault is pathognomonic of PPROM (3).  The ultrasound finding of oligohydramnios (amniotic fluid volume less than expected for gestational age) supports the diagnosis as @klone stated.  The fetus is small perhaps due to EJ's smoking.  The placenta is not supposed to block or cover the cervix, an abnormal condition called placenta previa.  There are a number of tests used to establish the diagnosis as well but I won't get into that at this point.  These are typically done if there's still a question of alternative causes such as urinary incontinence for example.

Plan

Let's recap what was mentioned about EJ's care plan.  Monitoring of vital signs is important just as in other patients who are admitted. As everyone already mentioned, infection is a big concern.  Again, I'm giving this up to our L&D nurses here for giving accurate answers. 

As per usual, you would expect CBC and maybe electrolytes.  The WBC with differential will be a piece in the puzzle in determining presence of infection as would body temperature, heart rate, and the quality of lady partsl discharge.

In the absence of other worrisome findings, there are differing camps within Obstetricians on deciding between "expectant management" which is watching and waiting vs delivery.  You are welcome to share what you've seen in practice.   

Again, hats off to our L&D nurses who are so used to caring for expectant mothers for recognizing fetal health as another concern.  Fetal monitoring and steroids as mentioned are interventions meant to assess and protect fetal well being.  Thanks for participating.

Tune in on Saturday, Sept 5 for the next update on EJ.

References:

(1) Mercer BM, Preterm Premature Rupture of Membranes: Current Approaches to Evaluation and Management, Obstetrics Gynecological Clinics of North America, September 2005.

(2)(3) Duff P, Preterm Prelabor Rupture of Membranes: Clinical Manifestations and Diagnosis, UpToDate, updated May 29, 2020.

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
On 9/2/2020 at 9:12 AM, JKL33 said:

ETA--ooh a question: Are other infections (UTIs, STIs, BV, etc.) just found to be not as likely as GBS, or why do we not have to concern ourselves with those (e.g. test for them or cover them?)

**

Also, thanks @juan de la cruz for posting the case.

Glad you are liking the case. 

GBS is reported to colonize the genital tracts of many pregnant women and vertical transmission to the newborn is a concern which could lead to a host of problems.  Per the CDC data, 1 in 4 pregnant women carry the bacteria in their body (1).  I've read an expert opinion about routine testing for BVI and chlamydia trachomatis in PPROM cases as well but there is no consensus on that.

I  would have to say that in cases where other infections are suspected (like UTI's, endometritis, or chorioamnionitis as  you mentioned that are not just caused by GBS alone), there should be a low threshold to cover those infections with empiric broad spectrum antibiotics until cultures are available. 

Reference

(1) https://www.CDC.gov/groupbstrep/about/fast-facts.html

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Hospital Day 3

EJ has received a course of corticosteroids.  Her fetus was found to be in the ideal cephalic presentation.  The OB team decided on labor induction with oxytocin as there were no contraindications identified.  EJ requested an epidural and a CRNA placed the catheter successfully.  Continuous epidural infusion of ropivacaine and fentanyl was started.

Focused Nursing Assessment:

Neuro: alert and oriented, anxious

CV: S1S2 normal, NSR with HR 87, BP 122/80

Pulm: lung sounds CTAB, O2 sat 99% on RA

GI/GU: gravid abdomen, odorless and clear lady partsl discharge

ID: Temp 36.5

Labs:

WBC 11 k/UL
Hgb 12 g/DL
Hct 33%
Plt 150  k/UL
INR 1.1
PTT 30 sec
Fibrinogen 300 mg/DL
Type and Screen O positive
GBS not detected
HIV negative
COVID 19 PCR not detected

Delivery Course:

EJ had an uncomplicated labor course thus far and delivered a low birth weight baby girl.  Her newborn was transported to the Neonatal ICU.

Within 30 minutes of manual placental removal, EJ stated "I am not feeling well" and immediately became unresponsive.  Within seconds, she was pulseless and blue.  A Code Blue was called.  Teams from Anesthesiology and Adult Critical Care Medicine arrived to assist the OB team. 

The anesthesiologist was able to secure a #7.5 endotracheal tube and ventilate while the rest of the Code Blue Team did CPR.  Medication administration following ACLS protocol for asystole was carried out.  An arterial line was placed in the left femoral artery emergently.

During the event, she started gushing blood out of her lady parts.  A percutaneous sheath introducer (PSI) was emergently placed by the ICU team on the right femoral vein and Massive Transfusion Protocol (MTP) was activated.  Using a Rapid Infuser, a total of 8 Units of PRBC, 8 Units of FFP, and 4 Units of platelets were rapidly transfused. The OB team placed a Bakri balloon for temporary hemostasis.

Return of Spontaneous Circulation (ROSC) was achieved after 30 minutes. EJ was transferred to the ICU.

Post-Arrest assessment:

Neuro: unresponsive to stimuli, pupils are equal 3 mm, reactive to light

CV: S1S2, Tele: Sinus Tach 110's with some PVC's, Arterial Line BP of 93/50 with MAP of 67, CVP 18.

Pulm: Lung sounds coorifice bilaterally. Os sat 95% (see vent settings)

GI: abdomen soft, ND, hypoactive bowel sounds

GU: Bakri balloon and Foley catheter in place

Extremities:  cool to touch, slow capillary refill

ID: temp 36.2 C

Medications:

Propofol at 30 mcg/kg/min

Epinephrine at 0.03 mcg/kg/min

Norepinephrine at 13 mcg/min

Vent settings and lung mechanics:

Ventilated on Assist Control/Volume Control, set RR 28, VT 350 (calculated as 6 cc/kg of her predicted body weight), FiO2 100%, PEEP 15, peak airway pressure 32, plateau pressure 26.

Imaging:

CXR:

cxr-e1539817072332.png.b164873bc9fac81680cf451003d427d8.png

CT brain:

No large vessel ischemia, multiple small vessel supra and infratentorial embolic infacts.

CT abd/pelvis:

hepatic infarcts.

Transthoracic Echocardiogram:

LV dysfunction with EF 35%, regional hypokinesis in the mid and apical segments. RV function and volume were normal. No valvular disease. IVC was full and does not collapse.

Laboratory Data:

WBC 14 k/UL
Hgb 8.4 g/DL
Hct 24%
Plt 34 U/L
INR 2.4
PTT 63 sec
Fibrinogen 73 mg/DL
AST 960 U/L
ALT 752 U/L
total bili 3 mg/DL
alk phos 320 U/L
Na 133
K 3.7
Cl 100
CO2 23
BUN 30
crea 0.8

ABG:

pH 7.28 paCO2 50 PaO2 134 HCO3 22 Base excess -3

 95%

lactate 3
BNP 950

Questions:

What do you think happened to EJ? Putting all the data together, make some inferences on what the labs and diagnostics mean. What next steps would you anticipate? ICU nurses I expect a system-based response, ie, plan per Neuro...CV...Pulm, etc.

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

I'm confident I know what is going on, but I will let someone else chime in first. ?

Me too...?

No, I seriously do think the findings are kind of straightforward, are they not (?)

Specializes in Vents, Telemetry, Home Care, Home infusion.

My hunch in my first post.... will let an OB nurse further explain..

 

Okay so this is not completely straightforward after all, but I will give the answer I have in mind:

- I believe the cause of the uterine hemorrhage and multiple embolic infarcts on brain CT and hepatic infarcts on abd CT is due to DIC, which is consistent with the uterine hemorrhage and the coagulation derangements noted (increased INR, decreased fibrinogen)

- Thoughts about what caused the DIC (pretty much in order of suspicion):

  • It was a manifestation of (normotensive) HELLP syndrome. (?)
  • It was due to uterine hemorrhage from retained placenta which required manual removal
  • I think placental abruption is less likely as this would have resulted in intrapartum bleeding?
  • I feel an amniotic fluid embolism is less likely in the setting of oligohydramnios (?)

- There is no mention of this patient having chronic liver disease or suspicion of other liver problem. So I will go with the idea that all of this (elevated liver enzymes, low platelets and subsequent manifestations of DIC) is due to HELLP.

-LVEF related to inflammatory response involved in HELLP. Elevated BNP secondary to HFrEF.

??‍♀️

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

@JKL33, it is certainly a DIC picture in the context of a Post-Partum Hemorrhage.  Those are good differentials. 

 

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Just wanted to say that I encourage free discussion here and there should be no judgement on what people give as answers.  Part of practicing the "healing arts" is making inferences based on the data and working through probabilities of what might be happening.  So yes, make guesses and state your thought process.

Specializes in L&D, OBED, NICU, Lactation.
21 hours ago, klone said:

I'm confident I know what is going on, but I will let someone else chime in first. ?

I think I'm with you. If I'm right, we were just talking about this at work the other day and WAY too few people have ever heard of the acronym that helps both identify the condition and the initial treatment for it.

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

Okay, I know labor dude and I are on the same page. I'm going to diagnose this patient with an AFE (amniotic fluid embolism). Even though it's rare, the hallmark sign that that is what is going on is this:

Quote

Within 30 minutes of manual placental removal, EJ stated "I am not feeling well" and immediately became unresponsive. 

This is typically how an AFE presents: at or around delivery of the placenta, the woman will suddenly feel unwell, nauseated, SOB, or express an impending sense of doom. 

The treatment (as labordude alluded) is immediate administration of the medications known by the acronym A-OK (atropine, ondansetron, and ketoralac). 

AFE will usually quickly develop into DIC, which is why she suddenly hemorrhaged once she became unresponsive. 

Other than A-OK protocol, treatment is supportive - blood products, volume expanders, treatment for cardiac arrest, transfer to ICU. Mortality is around 50-80%. And this is where I tag the ICU nurse. Baby's born, I'm outside my wheelhouse now. I'm happy to assess her  Bakri q2h, but that's about it. ?

There is a FASCINATING book called "37 Seconds" which is a woman's firsthand account of surviving AFE (and KNOWING before she even went into labor that she was going to die in childbirth - she spoke at the 2017 AWHONN annual conference in New Orleans).

So AFE then DIC then MODS...

?