Case Study: An OB Catastrophe

The following is a case simulation involving a patient initially encountered in Labor and Delivery. While the initial encounter occurred in a specific setting, this particular case will evolve and include transitions to various specialty areas over the healthcare continuum.

Updated:  

Case Study Objectives

  1. Present a simulated case as it evolves over time.
  2. Encourage open discussion from nurses that represent a variety of specialties.
  3. Promote learning based on the:
    • details of the case
    • evaluation of the data
    • known interventions in order to provide holistic care
  4. Recognize maternal morbidity and mortality as a serious public health issue facing the world.

Introduction

The initial presentation that will proceed is meant to set the tone for the next set of events that will occur. I would like to preface by saying that this particular part of the case is where I have no actual nursing experience so I encourage colleagues who work in this specialty area to chime in with their responses.

Let's keep this lively, but also make sure we are respectful of each other.  Remember that we work in different hospitals and protocols may be different.  Also, be aware that while the following scenario seems "garden variety", it will get more "exciting" as we move along.

Case Specifics

History / Presentation

EJ is a 32-year old, Gravida 4 Para 2, at 34 weeks and 2 days gestational age. She has no chronic medical problems but admits to current tobacco smoking since age 17.  She says that she has been trying to quit and has cut back her smoking to 2-3 cigarettes a day.  She lives with her husband and two children ages 3 and 5 in a 2-bedroom apartment. 

She receives prenatal care at an urban Federally Qualified Healthcare Center (FQHC).  She previously worked as a server at a restaurant but has become unemployed for a couple of months due to restaurant closures from the coronavirus pandemic.  She has good family support from her parents and her husband, RJ, who is a delivery truck driver.  She is insured through her husband's coverage. 

Today, she called her Women's Health Nurse Practitioner (WHNP) when she experienced a gush of watery fluid from her lady parts while playing with her children.  She was told to come to OB Triage at the nearby Tertiary Medical Center Antepartum Unit.  Upon presentation, she was seen by the OB Triage nurse who found her anxious but well-appearing. 

Vital Signs

  • Temperature: 36.7 degrees C
  • Heart Rate: 84
  • Respiratory Rate: 16
  • Blood Pressure: 112/74
  • O2 Saturation: 96% RA
  • Fetal Heart Rate (FHR): 140

Physical / Pelvic Examination

An OB-Gyn resident saw EJ and performed a physical examination that revealed clear, pale yellow, odorless fluid leaking out of her endocervical canal with pooling in the lady partsl vault.

Diagnostic Studies

The OB-Gyn resident performed ultrasonography which revealed:

  • oligohydramnios
  • a fetus that is small for its age, without birth defects, in no distress
  • a placenta that does not cover the cervix

Recommendation

The OB-Gyn team recommended admission to the Antepartum Unit.

Diagnosis

At this point, EJ's diagnosis seems obvious but you are welcome to state it in your response to the thread.

1 - As EJ's nurse, state some assessment findings that would make you concerned. 

2 - As the nurse in that unit, what laboratory tests and monitoring procedures would you anticipate in this case, and why?

Specializes in Nurse Leader specializing in Labor & Delivery.

You’re right - It used to be thought that entry of fetal cells into maternal circulation is what caused AFE, but now we know that fetal cells are present in maternal circulation a good percentage of the time without untoward effects. It’s believed that in a tiny percentage of women, this causes a sudden anaphylactic reaction. I haven’t heard that there is a big push to rename AFE, however. 

On 9/7/2020 at 2:12 AM, frozenmedic said:

"Anaphylactoid Syndrome of Pregnancy?"

On 9/7/2020 at 8:19 AM, klone said:

It used to be thought that entry of fetal cells into maternal circulation is what caused AFE, but now we know that fetal cells are present in maternal circulation a good percentage of the time without untoward effects.

Sorry: ?.

I hope it is fair to say that others' misunderstandings are somewhat understandable.

I feel really, really stupid. Extremely.

But....I doubt I am the only one who has thought of this condition as microbubbles of actual amniotic fluid entering maternal circulation and very rarely causing a mechanical catastrophe?

I just read this paper and am not qualified to endorse it overall but it includes some basic discussion of the pathophysiology involved and the A-OK treatment, including a helpful graphic.

https://www.researchgate.net/publication/312332674_Atypical_Amniotic_Fluid_Embolism_AFE_Managed_With_A_Novel_Therapeutic_Regimen/link/5a3b50da458515a77aa99a21/download

ETA: Although it isn't fun being the ignorant one on this thread, I have found it fascinating and have learned a lot...so thank you to all of you!

Specializes in Vents, Telemetry, Home Care, Home infusion.

Thank you--- this is the best article + CSI posted at allnurses.  Thirty years since I worked in the hospital, ondansetron was yet to be FDA approved drug, yet  alone recommended for this condition.

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Love the discussion!

I think I can also add to the ICU management here since that's really my area of expertise. Thanks @frozenmedic for starting the discussion on ICU care.

Neuro:

As in other post-arrest situations, Targeted Temperature Management (TTM) should be considered.  Given her coagulopathy, our institution would tend to favor a target of 36 degrees (1).  There is evidence that both 33 and 36 degrees have similar outcomes.  Our Neurologist feel that really the goal is not let the patient be febrile.  The brain CT findings though sad is actually not too bad given there are no large vessel occlusions but rather micro embolis.  She may have memory problems, occasional confusion, and balance problems later on (infratentorial being cerebellum).  Some women who had AFE have it worse - anoxic brain injuries are not uncommon.

CV:

Agree with weaning Epinephrine first.  Surprisingly Dobutamine wasn't started?  But I made this case this way to show that sometimes in a Code Blue situation, drugs get started and are kept running if it's working and keeping the patient alive.  Epinephrine can cause lactate elevation as well and is an agent that can make pulmonary vascular resistance go up.  Stress Induced Cardiomyopathy has a good prognosis. Diurese when safe to do so.  Consult Cardiology, she could transition to goal-directed medical therapy (beta blockers, ACEI, ARB) if she gets weaned off the pressors and remains stable from a hemodynamic standpoint.

Pulm:

You can argue ARDS here but likely not.  She had a cardiac insult and volume overload explains the pulmonary edema, hence, the Berlin Criteria rules it out (2).  She, however, will still benefit from lung protective ventilation which has shown to help patients in the long run (keeping tidal volumes 6 cc/kg and plateau pressures less than 30 (3).  

GI:

Nutrition is important!  Place a feeding tube and trickle feed enterally, advance as tolerated. GI prophlaxis is also indicated. Trend those LFT's. Portal vein thrombosis needs anticoagulation at some point.

Renal:

Definitely at risk for Acute Kidney Injury given the Code Blue, DIC, etc. Check electrolytes frequently! Hypocalcemia and hyperkalemia are consequences of MTP.

Heme:

Consult a Hematologist regarding the DIC.  Heparin has been used in DIC after bleeding is controlled which seems unsafe but it's supposed to help halt the coagulation that triggers the cascade of fibrinolysis and consumption.  If that is to be employed, I would be comfortable if Hematology is guiding it.  Transfuse, transfuse, as needed.  She needs cryoprecipitate.  Tranexamic Acid has been used for this type of bleeding in case reports.  Every facility has a Massive Transfusion Protocol (MTP), this one is from Rush (4).  Ask anesthesia about timing for epidural removal which is precarious at this point - can lead to epidural hematoma which is bad, like lower extremity paralysis bad.

ID:

Doesn't seem infected but definitely high risk for it.  Take out those emergency lines (A line and fem line) as they were placed suboptimally and in non-sterile conditions.  Place fresh lines in the ICU following the proper steps.  VAP prophylaxis per protocol.  Bakri balloon needs antibiotic prophylaxis! Ask OB's preference.

Endocrine:

Stress induced hyperglycemia could happen, hence, watch sugars and start low correctional scale if needed.

OB:

Watch Bakri balloon drainage and defer to OB for timing of removal. Lactation specialist to assist RN's with "pump and dump" procedure.

 

References:

(1) Nielsen et al. Targeted Temperature Management at 33 C versus 36 C after Cardiac Arrest. New England Journal of Medicine. 369 (23): 2197–206. (2013)

(2) https://www.mdcalc.com/berlin-criteria-acute-respiratory-distress-syndrome

(3) http://www.ardsnet.org/files/ventilator_protocol_2008-07.pdf

(4) https://rushemergencymedicine.org/2019/04/22/mtp-in-a-rush/

 

anything else anyone can add?

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Just wanted to add and I'm sure the ICU nurses can relate...this is a situation when more than 2 ICU nurses need to be in the room helping the primary ICU nurse, LOL.

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
On 9/7/2020 at 10:11 AM, JKL33 said:

Sorry: ?.

I hope it is fair to say that others' misunderstandings are somewhat understandable.

I feel really, really stupid. Extremely.

But....I doubt I am the only one who has thought of this condition as microbubbles of actual amniotic fluid entering maternal circulation and very rarely causing a mechanical catastrophe?

I just read this paper and am not qualified to endorse it overall but it includes some basic discussion of the pathophysiology involved and the A-OK treatment, including a helpful graphic.

https://www.researchgate.net/publication/312332674_Atypical_Amniotic_Fluid_Embolism_AFE_Managed_With_A_Novel_Therapeutic_Regimen/link/5a3b50da458515a77aa99a21/download

ETA: Although it isn't fun being the ignorant one on this thread, I have found it fascinating and have learned a lot...so thank you to all of you!

There is a widespread push to use the A-OK protocol but I think there is some camps that feel that there is not enough empiric evidence yet to support it.  The theoretical basis of it was gleaned from animal studies.  AFE is so rare that human studies are very difficult to even conduct.  The first use of A-OK, I believe was in 2013.  The case report you posted is a good one, it questions the criteria proposed by the MFM Society and AFE Foundation because they actually gave A-OK in a patient that didn't have all the elements of the diagnostic criteria. The treatment is so widely available, there shouldn't be any hesitation to use it.

There seems to be a lot of internet resources on A-OK from the CRNA's. Here's one presented by CRNA students at UPenn:

https://cdn.ymaws.com/www.pana.org/resource/resmgr/docs/a-ok2019studentpresentation..pdf

Specializes in Nurse Leader specializing in Labor & Delivery.
On 9/7/2020 at 1:20 PM, juan de la cruz said:

OB:

Watch Bakri balloon drainage and defer to OB for timing of removal. Lactation specialist to assist RN's with "pump and dump" procedure.

You sure about that? ?

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
1 hour ago, klone said:

You sure about that? ?

Well, I'm speaking for the ICU nurses at work who often aren't aware how it's done. Dump because the continuous sedation meds we give in the ICU transfers into mother's milk. 

Specializes in Nurse Leader specializing in Labor & Delivery.

Are you sure that it’s contraindicated for the infant?

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
5 minutes ago, klone said:

Are you sure that it’s contraindicated for the infant?

I believe most studies determined presence of propofol, fentanyl, midazolam, etc on women who underwent procedural sedation. It's not well studied as far as I know in women who are on continuous infusions of these meds.  Their blood levels are constantly maintained on a continuous infusion.  Our practice is to not use these subset of infant milk.

Specializes in Nurse Leader specializing in Labor & Delivery.

Are you familiar with Thomas Hale’s “Medications and Mother’s Milk”? That’s the text that we rely on to determine if a medication is okay with breastfeeding. 
 

As far as I know, those meds are all okay with breastfeeding. But I would need to look them up at work tomorrow. 

This is an issue that is very common in the healthcare setting - the lack of knowledge of lactational pharmacology, and the ubiquitous recommendation to “pump and dump” when it’s actually not necessary. 

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
42 minutes ago, klone said:

Are you familiar with Thomas Hale’s “Medications and Mother’s Milk”? That’s the text that we rely on to determine if a medication is okay with breastfeeding. 
 

As far as I know, those meds are all okay with breastfeeding. But I would need to look them up at work tomorrow. 

This is an issue that is very common in the healthcare setting - the lack of knowledge of lactational pharmacology, and the ubiquitous recommendation to “pump and dump” when it’s actually not necessary. 

I looked at his work. It's the same as what one can find in lactmed: https://www.ncbi.nlm.nih.gov/books/NBK501922/?term=.

The data on those meds I mentioned do not cover continuous infusions except maybe in fentanyl where there were reports of mothers using a patch and breastfeeding (which in theory is similar to a drip).  I still find it hard to believe that a combination of these drugs that basically put a woman in an "induced coma" would be safe for an infant much less a preemie.