Case Study: An OB Catastrophe

The following is a case simulation involving a patient initially encountered in Labor and Delivery. While the initial encounter occurred in a specific setting, this particular case will evolve and include transitions to various specialty areas over the healthcare continuum. Specialties Critical Case Study

Updated:  

Case Study Objectives

  1. Present a simulated case as it evolves over time.
  2. Encourage open discussion from nurses that represent a variety of specialties.
  3. Promote learning based on the:
    • details of the case
    • evaluation of the data
    • known interventions in order to provide holistic care
  4. Recognize maternal morbidity and mortality as a serious public health issue facing the world.

Introduction

The initial presentation that will proceed is meant to set the tone for the next set of events that will occur. I would like to preface by saying that this particular part of the case is where I have no actual nursing experience so I encourage colleagues who work in this specialty area to chime in with their responses.

Let's keep this lively, but also make sure we are respectful of each other.  Remember that we work in different hospitals and protocols may be different.  Also, be aware that while the following scenario seems "garden variety", it will get more "exciting" as we move along.

Case Specifics

History / Presentation

EJ is a 32-year old, Gravida 4 Para 2, at 34 weeks and 2 days gestational age. She has no chronic medical problems but admits to current tobacco smoking since age 17.  She says that she has been trying to quit and has cut back her smoking to 2-3 cigarettes a day.  She lives with her husband and two children ages 3 and 5 in a 2-bedroom apartment. 

She receives prenatal care at an urban Federally Qualified Healthcare Center (FQHC).  She previously worked as a server at a restaurant but has become unemployed for a couple of months due to restaurant closures from the coronavirus pandemic.  She has good family support from her parents and her husband, RJ, who is a delivery truck driver.  She is insured through her husband's coverage. 

Today, she called her Women's Health Nurse Practitioner (WHNP) when she experienced a gush of watery fluid from her lady parts while playing with her children.  She was told to come to OB Triage at the nearby Tertiary Medical Center Antepartum Unit.  Upon presentation, she was seen by the OB Triage nurse who found her anxious but well-appearing. 

Vital Signs

  • Temperature: 36.7 degrees C
  • Heart Rate: 84
  • Respiratory Rate: 16
  • Blood Pressure: 112/74
  • O2 Saturation: 96% RA
  • Fetal Heart Rate (FHR): 140

Physical / Pelvic Examination

An OB-Gyn resident saw EJ and performed a physical examination that revealed clear, pale yellow, odorless fluid leaking out of her endocervical canal with pooling in the lady partsl vault.

Diagnostic Studies

The OB-Gyn resident performed ultrasonography which revealed:

  • oligohydramnios
  • a fetus that is small for its age, without birth defects, in no distress
  • a placenta that does not cover the cervix

Recommendation

The OB-Gyn team recommended admission to the Antepartum Unit.

Diagnosis

At this point, EJ's diagnosis seems obvious but you are welcome to state it in your response to the thread.

1 - As EJ's nurse, state some assessment findings that would make you concerned. 

2 - As the nurse in that unit, what laboratory tests and monitoring procedures would you anticipate in this case, and why?

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

One needs to keep in mind that the amount that goes through to the breastmilk is a very tiny percentage. Also, there is the question of oral bioavailability, as well as protein binding. That’s why it’s not as straightforward as “this drug is strong, therefore it’s dangerous to the breastfeeding infant.”

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
10 minutes ago, klone said:

One needs to keep in mind that the amount that goes through to the breastmilk is a very tiny percentage. Also, there is the question of oral bioavailability, as well as protein binding. That’s why it’s not as straightforward as “this drug is strong, therefore it’s dangerous to the breastfeeding infant.”

Wait, these are continuous intravenous infusions as in delivered by an IV drip.  I totally get your concern about wasting a valuable nutrition source for an infant.  But you should look at the data on those meds I mentioned. You don't need to have Dr. Hale's book in front of you.  He doesn't do the tests himself, rather, he compiles the data on them just like Lactmed.  

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

I understand. And I will look them up tomorrow when I have the resources in front of me. Can you list what the specific medications are? Propofol, fentanyl? 

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
4 minutes ago, klone said:

I understand. And I will look them up tomorrow when I have the resources in front of me. Can you list what the specific medications are? Propofol, fentanyl? 

Sure, given that this hypothetical patient is going to start TTM, we would typically use both fentanyl and propofol infusions together. In situations where their cardiac function is compromised and propofol is affecting their hemodynamics, we would use midazolam instead.  We only really pump and dump on patients with continuous infusions for sedation and trust me, in San Francciso we have ultra nature fanatics who tell us mother's milk is a gift from heaven and must not be wasted. Mothers who get the occasional opioid PO for pain can breastfeed.

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

@klone Hi, since you're going to look up your practice, I will ask you to look something else up and this is totally off topic.  We have been getting a number of pregnant COVID19 patients and some of them have required intubation and emergent C sections.  They come back to the ICU intubated and on guess what, propofol and fentanyl, sometimes cisatracurium and we pump and dump.  But after extubation and no longer needing sedation we should be good for using their breastmilk.  However, there is some controversy on the COVID19 drug remdesivir and the jury here is hung because there is no data on it. What is your practice on remdesivir and breastfeeding?

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.
7 hours ago, juan de la cruz said:

Wait, these are continuous intravenous infusions as in delivered by an IV drip.  

Yes, I understand these are IV meds. My point regarding oral bioavailability is how bioavailable are these IV meds when ingested orally (by the infant). Many IV meds will pass right through the system when given orally, and have no effects whatsoever (thus, would be safe to the breastfeeding infant).

I will do some research today on those meds, as well as remdesivir, and let you know what I find.

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

Okay, reading about Propofol (continuous infusion). It’s categorized as L2 (probably compatible). Only very low concentrations are found in breastmilk, and it is rapidly cleared from neonatal circulation. Protein binding is 99%, which means that only minuscule amounts are able to enter the breastmilk (the higher the PB, then better). Relative infant dose is approximately 4.4% of maternal dose. 

In one study, the amount found in milk 4 hours after induction was 0.04-0.24mg/L. The amount in found in the milk 24 hours after induction (while on a continuous infusion) was only 6% of the original amount found in the 4-hour sample. Keep in mind that, particularly for the first few days, the volume of breastmilk that the infant actually receives can be measured in mLs. So actual amount of the drug present in those small amounts is so insignificant. 

No untoward effects on the infants exposed via breastmilk have been reported in several studies.

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

Fentanyl is also rated L2. It has low oral bioavailability, which means that very little  of what is in the milk will actually get into the infant’s bloodstream. According to Hale, “The relatively low level of Fentanyl found in human milk is presumably a result of the short maternal half-life, and the rather rapid redistribution out of the maternal plasma compartment. It is apparent that fentanyl transfer to milk under most clinical conditions is poor and is probably clinically unimportant.”

So, my expert opinion as an IBCLC is that it is not necessary for mom to pump and dump with either of these medications. 

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

Remdesivir - given IV because it is poorly absorbed orally. As such, infants are unlikely to absorb clinically significant amounts of the drug from milk. In addition, newborn infants have directly received remdesivir therapy of Ebola with no serious adverse drug reactions. 

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

I've actually seen those studies and some more than what you posted (through the Lactmed website).  The question remains, those patients stopped receiving those meds after their surgical procedure and there was a period of time that elapsed when they breastfed.  These meds are very short acting, I get that, I agree that it's safe in that situation. 

The mothers in question (in the ICU, on continuous drips) are still getting the meds.  There is no data in that population. I'm actually really curious if your institution saves the breastmilk for infant use of patients in the ICU intubated and sedated on these drips. Not just your opinion as an IBCLC because we have your peers on our staff too.

I also read up on remdesivir and I agree with your opinion on it though because of its hepatotoxic effect, I would have caution in an infact with liver issues.

I actually don't make the rules at work as an NP (my pay grade doesn't allow me that in an academic institution, LOL).  We have a whole panel of pharmacists, OB, Neonatologists, Pediatrics, etc who decided that.

Specializes in OB-Gyn/Primary Care/Ambulatory Leadership.

At least one of the studies on propofol was on women who were on a continuous infusion. But yes, most of the studies on Fentanyl focus on its use in labor. 

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
3 minutes ago, klone said:

At least one of the studies on propofol was on women who were on a continuous infusion. But yes, most of the studies on Fentanyl focus on its use in labor. 

Really? she was on propofol infusion and breastfeeding? The infusion was stopped and there was a period of time that elapsed when she breastfed if we're talking about the same study.  Can you post the one you're referring to here?