Breathless, Coughing and Run-down: What's Going On? | Case Study

A new case study in which the patient, a 32-yr-old white male presents to a local free clinic with fatigue, moderate dyspnea, and a persistent and non-productive cough. Nurses General Nursing Case Study

Updated:  

Chief Complaint

"For the past few days I've been feeling run-down. I can't stop coughing and I'm out of breath. It can't be COVID – I already had it a few months ago.”

History of Present Illness

The patient has struggled with homelessness for many years. He visits the free clinic every few months, most recently to be treated for Chlamydia and Gonorrhea after experiencing painful urination and swollen testicles. He states that his symptoms "came on fast.”

General Appearance

Patient is thin and sunburned. He looks more than his stated age, with many wrinkles and burst blood vessels in his nose. His clothing is too large and there is dirt on his pant legs, the creases in his neck and under his fingernails. His hair is long and tangled and in a ponytail. He appears sober and smells of body odor and cigarettes.

Past Medical History

  • RSV at 6 months
  • Treated for tuberculosis for 12 months with isoniazid 5 years ago
  • Perianal ulceration, positive for herpes 4 years ago topically treated with acyclovir and zinc oxide
  • MVA resulting in multiple herniated discs and fractures to spine 3 years ago
  • Tested positive for COVID-19 after experiencing mild fever and cough – he got tested when he lost his sense of smell 6 months ago
  • Chlamydia and Gonorrhea 3 months ago, treated with ceftriaxone and azithromycin.

Family History

No history given

Social History

  • Homosexual, admits to engaging in unprotected intercourse since the age of 18. He lives on and off with his 60 yo aunt "until she kicks me out.”
  • He is unemployed and receives social security disability checks for back pain related to the MVA.
  • He previously had worked for several different gas stations
  • He smokes at least one pack of cigarettes a day "if I can get them.”
  • He has a history of alcohol, cocaine, heroin and methamphetamine abuse.

Immunizations

Had tetorifice shot over 10 years ago but can't recall any others. He does have a COVID-19 vaccination card. "When I found out I could win the lottery, I went right in.”

Medications

None

Allergies

Red rash with Sulfa drugs

Vital Signs

  • BP 133/83 sitting, LA
  • HR 91
  • RR 30
  • T 101.8o F
  • HT 6' 3"
  • WT 150 lbs
  • BMI 18.7

What information do you need for a diagnosis?

What labs do you want?

What other diagnostic tests should we run?

Specializes in EMT/CPT/Outpatient Care/LTC.

covid shot dates and info 

Rainbow special for labs. So many differentials with this one.

Blood cultures x2

Blue (INR/PTT, D-dimer)

Yellow (viral and bacterial serology say HIV, STD) to query sepsis.

Green (Lytes, Urea, Creatinine Troponin, CK)

Lavender (CBC plus any addons)

Heparin (Lactate, blood gases)

Chest Xray, Chest CT pulmonary angio to rule out PE, pulmonary edema.

Also we should get an O2 sat (not shown) and start oxygen and ventolin if indicated and per hospital policy.

All the tests already mentioned but also I would want to know specifically what areas he beds down in and frequents. Asbestos? Hx of drug use could mean environmentally compromised areas. Emaciated appearance also points me in that direction. Any factories, toxic emissions? Close to a busy road? Sputum Cytology? R/O cancer.. Chest Xray, CAT Scan? Any pulmonary parasites from strange foods or cooking methods? Tidal volume? Blood gases? Definitely a pulmonary consult! 

Specializes in Oncology, Home Health, Patient Safety.

First Follow-Up Post

Tests: COVID-19 negative, positive for antibodies

Review of Systems - only abnormal values presented:

  • Skin: Rhynophyma (swollen, red, bumpy nose and cheeks), burst blood vessels on surface of nose, sunburn on face, neck and arms
  • HEENT: small, creamy white lesions are found on the sides of his tongue and the roof of his mouth.
  • Lymph nodes: slight cervical adenopathy
  • Lungs/Thorax: mild axillary lymphadenopathy, bibasilar crackles with auscultation
  • Musculoskeletal: demonstrates difficulty sitting and standing
  • Abdomen: mild to moderate inguinal lymphadenopathy

Chest X-ray: Bilateral diffuse interstitial disease without hilar adenopathy, mild cystic changes, no consolidation, or nodules

Laboratory Test Results (normal values):

  • Na 137 meg/L (135-145)
  • K 4.0 meq/L (3.5-5)
  • Cl 108 (101-112)
  • Mg 2.0 mg/dL (1.8-3)
  • PO4 3.9 mg/dL (2.5-4.5)
  • BUN 10 mg/dL (8-20)
  • Cr 0.8 mg/dL (0.6-1.2)
  • Ca 8.0 mh/dL (8.5-10.5)
  • Hb 10.8 g/dL males (13.6-17.5)
  • Hct 32.2% males (39-49%)
  • Plt 260,000 cu/mm (150,000-450,000)
  • WBC 3.8 x 103/mm3 (4,800- 10,800)
  • Neutros 68% (57-67)
  • Lymphs 18% (25-33)
  • Eos 1.5% (1-4)
  • Monos 11.5% (3-7)
  • Basos 1.5 (0-1)
  • AST 33 IU/L (0-35)
  • ALT 9 IU/L (7-56)
  • Glu fasting 114 mg/dL (60-110)
  • Total Bili 0.6 mg/dL (0.1-1.2)
  • Total Protein 6.5 g/dL (6-8.3)
  • Albumin 2.6 g/dL (3.4-4.7)

Urinalysis: minor dehydration, but otherwise WNL

 

Specializes in Public Health.

I’m leaning toward a respiratory infection given his respiratory rate and breath sounds. There is no consolidation which points away from pneumonia.  Lesions in mouth and cachexia could be thrush and general immunocompromise   May be anemia of chronic disease.

Negative COVID test suggests that previous COVID infection may have caused long term pulmonary damage

Differentials
interstitial lung disease of unknown origin (COVID associated, asbestosis? Silicosis?)

R/O TB though lack of cavitary lesions makes this unlikely

 

Admit to inpatient care. Isolate on airborne precautions for now. Continuous O2 monitoring.

Specializes in PICU.

I think also a T-cell count and Viral load.  Maybe also see if Segs and Bands could be added in... 

Specializes in Public Health, TB.

No HIV results yet? Is there a previous chest ray for comparison? 

Specializes in Oncology, Home Health, Patient Safety.

SECOND FOLLOW UP (final post next week):

Other tests:

Sputum specimen obtained with inhalation of 3% saline by ultrasonic nebulizer:

  • Methanamine silver stain positive (consistent with Pneumocystis infection)
  • Monoclonal antibody with immunofluorescence: + Pneumocystis

ABG (normal values)

  • pH 7.45 (7.35-7.45)
  • PaO2 69 mmHg (83-108)
  • PaCO2 30 mmHg (32-48)
  • SaO2 92% (>95%)

Yes, he’s got pneumonia, but there’s something else going on. What’s causing his oral thrush? What will you treat the pneumonia with given his allergies?

Specializes in Physiology, CM, consulting, nsg edu, LNC, COB.

The pneumocystis and accompanying ABGs are the tip. You don’t want us to post our answers so I won’t, but I gotta say I had this guy pegged at the beginning, seen waaay too many of him before.

The thrush is an opportunistic infection r/t immune deficiency, treat c the usual non-sulfa meds for yeast overgrowth. The fungal pneumocystis pneumonia (PCP) is also opportunistic r/t immune deficiency. Treat the PCP with TMP/Bactrim normally, but he’s allergic to sulfa, so possibly amphotericin if resistant (some advocate for clinda), and oxygen and rest as his A-a gradient is already showing signs of poor gas exchange, borderline resp alkalosis (nl PaCO2 is 35-45) r/t increased resp drive for hypoxia (PaO2 and sats low).

And of course, start treating his underlying condition.  

Specializes in Oncology, Home Health, Patient Safety.

Hannah banana- you are so on the right track! I’ll post the final results Monday. 

Specializes in Oncology, Home Health, Patient Safety.

FINAL POST

The diagnosis of pneumocystis pneumonia (fungal pneumonia), oral thrush and his history of unprotected intercourse leads you to test him for HIV.

More lab tests:

  • CD4 cells 15% (25-65)
  • CD4 cells/mm3 30 (500-1200)
  • CD8 cells 28% (10-30)
  • CD8 cells/mm3 210 (336-780)
  • CD4/CD8: 0.14 (1.5-2.5)
  • HIV RNA 70,000 copies/mL

Positive lab test for HIV with both ELISA and Western blot

The patient admits to supplementing his income with sex work. He is treated with fluconazole for the thrush, erythropoietin for anemia, Primaquine 15-30 mg PO PLUS Clindamycin 600 mg IV for the pneumonia. In addition, antiretroviral therapy (ART) will be started to treat AIDS.

Acquired immunodeficiency syndrome (AIDS) is a chronic, possibly life-threatening illness caused by the sexually transmitted human immunodeficiency virus (HIV), though it can also be spread during childbirth or by contact with infected blood. HIV interferes with your body's ability to fight infection and disease by damaging the Helper T/CD4 cells of the immune system. The fewer CD4 T cells you have, the weaker your immune system. AIDS is defined as having a CD4 count below 200.

About 1.2 million people in the US have HIV. About 13 percent don’t know it. It disproportionately impacts people of color, gay, bisexual and other men who have sex with men. In 2019 there were an estimated 34,800 new HIV infections in the US. The CDC recommends that everyone aged 13-64 be tested at least once. Those at high risk should be tested at least annually.

Untreated, HIV typically turns into AIDS in about 8 to 10 years. It’s important to teach those with high-risk behaviors such as having unprotected sex, an STI and use of IV drugs the importance of getting tested for HIV regularly, since catching it before it destroys the immune system can lead to a long and healthy life. For therapy to be successful, patients need counseling and support since ART must be taken as prescribed without missing or skipping doses. Patients also may need help with dealing with the diagnosis as well as with discussing HIV status with future partners.

Signs and Symptoms:

Those infected by HIV can develop a flu-like illness within two to four weeks after the virus enters the body. This illness, known as primary (acute) HIV infection, may last for a few weeks.

Signs and symptoms such as swollen lymph nodes, diarrhea, weight loss, oral thrush, shingles and pneumonia may occur.

Progression to AIDS

Due to antiviral treatments, most people with HIV in the U.S. don't develop AIDS. When AIDS occurs, immune system damage may lead to the development of opportunistic infections or opportunistic cancers. Signs and symptoms may include:

  • Sweats
  • Chills
  • Recurring fever
  • Chronic diarrhea
  • Swollen lymph glands
  • Persistent white spots or unusual lesions on your tongue or in your mouth
  • Persistent, unexplained fatigue
  • Weakness
  • Weight loss
  • Skin rashes or bumps

Infections and complications common to HIV/AIDS

  • Pneumocystic pneumonia (PCP)
  • Candidiasis (thrush)
  • Tuberculosis
  • Cytomegalovirus
  • Cryptococcal meningitis
  • Toxoplasmosis
  • Lymphoma
  • Kaposi’s sarcoma
  • Wasting syndrome
  • Neurological complications
  • Kidney and liver disease

Once a person is diagnosed with AIDS, they can have a high viral load and are able to transmit HIV to others very easily. Without treatment, people with AIDS typically survive about 3 years.

References

Specializes in retired LTC.

Isn't it sad that some 35+yrs later, still no effective vaccine for HIV/AIDS??