Curious about something...Anyone heard of droperidol given for migraines?

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    I'm an lpn at a memory care currently so I of course deal with many kinds of psychotropics but was not thinking clearly when this med was given to me...I suffer from migraines and the other day had one so severe I went to the er. I had done this once before and a mix of iv benadryl and reglan did not help just morphine. I told the doc this info this past time, and he ended up ordering me a 5mg im shot of droperidol. The pain was so severe I didn't question it or ask questions but the nurse said to me, you should feel better soon he gave you a higher dose than usual. Shot was given and knocked me out so I didn't feel the pain anymore. Got home from the er at ten pm and was passed out within five mins again. I woke up twice the next day, once to call in and once to return a call from my boss. I then slept til ten pm that night when I finally dragged myself out of bed to eat then went back to sleep til 7am. So that's about 30-32 hrs of sleep. I can't describe it any other way other than I was "snowed". Literally. What a terrible feeling, tried to get oob but could not do it. Felt like I was watching myself try to do things. Trapped in my own mind basically. After looking into this drug its an antiemetic, antipsychotic, and one other thing I can't remember possibly antidoperagonist? Anyway, everything I read says to start initial dose at 2.5mg, Im or iv, then increase by 1.25mg. Also says to monital blood pressure which was done right before I was discharged and not any other time. For some reason I'm just bothered by this. I guess because I missed a day of work taking care of my residents because I was too doped up to go in. Anyone heard of this given for migraines? Sorry for the novel this just happened Sunday and has been on my mind!

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  2. 14 Comments...

  3. 0
    Droperidol┬* (Inapsine « ) -┬* Intravenous (IV) Dilution
    interesting, there was one article on pub med, if it is so great, why not more ? also, both this and the one on pubmed said 2.5 mg.
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    It's a NON FDA labelled med for headaches and migraines according to Micromedex
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    We use it in PACU for post op nausea that doesn't respond to Zofran. I usually give only 0.625 mg IV. It causes them to be drowsy and sleep for a while. Seems you got a high dose. Not sure about use for migraines.
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    I have seen it used one time for migraines with good results. It is an off label use for this med.
    Altra likes this.
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    I was given it for refractory vomiting last summer. All I know is that I thought I was dying, so I would've taken anything the MD offered. I remember the MD explaining that I needed to have an EKG prior to receiving it, and remain on a continuous tele monitor. I can say that I didn't vomit again after the med, but that might be because of how doped up it made me. It sort of felt like an EPS reaction when Reglan's IVP is given too fast; I wanted to jump out of my skin, but was too exhausted to move, let alone jump
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    At my facility we give it not all the time but frequently for migraine headaches in combination with usually benedryl. It works really well!!!
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    Worst, I mean worst experience of my life! Same thing happened to me. I was transported to the ED for severe migraine from work and was given this drug by iv and I had a very similar experience. At the ED i felt like i couldnt speak or think. Felt like my brain was broken. I remember being so afraid that it wouldn't go back to normal. I slept and still felt trapped in my mind. It's the absolute worst feeling. Eventually it faded but it took a while. This happened to me maybe 2 years ago and still remember it vividly.
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    Living with migraines can be a bear. This is an effective off-label use of Droperidol -- if Benadryl/Reglan don't work then the other choices include Droperidol or narcotics, which present their own set of problems, including a high frequency of rebound headaches after the initial pain relief -- not a desirable way to treat a headache.
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    If you are living with migraines like I was try going on daily Topamax. It was the best thing I have ever done. It was rough fighting through the initial side effects fir the first two months but buy now the headaches I do have are less worse and Ive bern almost migraine free.

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