Zofran

[Paramedic51]

Is Zofran an NSAID? And can it be administered to a patient with a GSW (gun shot wound) to the abdomen??

[klone, MSN, RN]

Someone said it was an NSAID

Who said that?

No, ondansetron (Zofran) does not have anti-inflammatory effects.

[Paramedic51]

I know what it's for. It's an antiemetic and I was gonna give zofran was senior medic said give phenergan because zofran is NSAID and he's been shot in abdomen

[klone, MSN, RN]

To know if it's an NSAID, you would have to know the mechanism behind how it works. Does Zofran inhibit or promote prostaglandin production in any way?

[KelRN215, BSN, RN]

I know what it's for. It's an antiemetic and I was gonna give zofran was senior medic said give phenergan because zofran is NSAID and he's been shot in abdomen

It's not an NSAID. Have you ever given NSAIDs for nausea/vomiting? Advil? Aleve? Celebrex? Toradol? Right, no, because NSAIDs are for pain/inflammation not nausea. Zofran is a selective 5-HT3 receptor antagonist.

[Paramedic51]

Please don't try to show off. I asked a question please give me a straightforward respectable answer

[Lev, MSN, RN, NP]

Please don't try to show off. I asked a question please give me a straightforward respectable answer

She was trying to educate you, not show off. Your straightforward answer is: No, it's not an NSAID. Any more questions?

[K+MgSO4, BSN]

Well okay then.

[akulahawkRN, ADN, RN, EMT-P]

Please don't try to show off. I asked a question please give me a straightforward respectable answer

It's not showing off. Zofran is a selective 5-HT3 antagonist, not an NSAID. They work in very different ways. In other words, Zofran is good for inhibiting nausea and keeps the barfing to a minimum. Your Senior Medic was incorrect in stating that Zofran is an NSAID.

[Paramedic51]

It's not showing off. Zofran is a selective 5-HT3 antagonist, not an NSAID. They work in very different ways. In other words, Zofran is good for inhibiting nausea and keeps the barfing to a minimum. Your Senior Medic was incorrect in stating that Zofran is an NSAID.

If you have a patient with a gsw to abdomen which would you prefer zofran or phenergan for nausea/vomiting and why?

[That Guy, BSN, RN, EMT-B]

Phenergan so they are narc'd out and sleepy.

[wheeliesurfer]

Correct answer?...Whatever works!! It will basically come down to provider preference. Unless you are a provider and have prescriptive authority it is not your call to make. If you are a medic, go by the standing orders your medical director lets you practice under.

[akulahawkRN, ADN, RN, EMT-P]

Given a choice, I would probably prefer Zofran over Phenergan as Phenergan is an antihistamine (blocks H1) and can be sedating and can antagonize other sedating drugs. I would expect less sedation with Zofran and after surgery, the patient can be given more Zofran PRN.

If I'm not given a choice, I would go with whatever my Medical Director would say that I have to use. Both do have their place though.