IV Phenergan and Toradol "Push"

Specialties Emergency

Published

Just thought I would bring a recent experience up for discussion:

29 May I end up in ER w/24 hours of extreme chills (long sleeve T-shirt, PJs, 2 blankets, quilt and down sleeping bag), intermittent, transient bone and joint pain, nausea and vomiting. I was given an IV set near the base of the thumb for fluids and then an IV "push" of phenergan and toradol at the site of the IV set rather than up the line where it would have been somewhat diluted. As a 30 year Crohn's disease patient I have had PLENTY of IV and IM phenergan and demerol w/o any discomfort or problems. But this one BURNED and HURT! The nurse continued the "push" and explained that it was the phenergan. I didn't really believe this given my previous experiences and assumed it was really the toradol as that was my first experience with it. The pain and burning only lasted a few minutes after the "push".

I had no swelling of the hand or arm, no pain, no redness for several days. Long enough that I never even thought of the IV push when I began with a bruised type feeling on the inside of the arm just above the wrist and the outside of the arm 1/2 below the elbow. Several days after that I did notice a hard stretch of vein about 3/4" long 1/2 way below the elbow on the outside of the arm. Later a "bump" at the wrist, still later another 3/4" hard stretch of vein just above and a little to the outside of the bump. And then a 1/2" hard spot in the vein below the base of the thumb at the wrist. It finally occured to me that this was probably the result of the IV push but since there was no redness, no swelling, no tenderness unless I kept poking the areas I didn't bother seeing a doctor about it. (Heaven knows I see him enough as it is, bless his heart!).

21 July the "bump" at the wrist turned red and was tender. Hot compresses did nothing for it that evening nor the next morning. My family doctor isn't in the office on Fridays and I figured the ER IV push was the cause so I went to ER. I was told it was "just" superficial thrombophlebits that could take as much as 6 months to resolve and was about to be released (which was ok with me as long as the doctors weren't concerned). But the "lead" ER doctor came in, first time I had seen her, and she said she would feel more comfortable ordering a venous ultrasound before I was released as she had had 2 STs go "sour" on her in the previous 3 months. I didn't have a problem with that so of course I agreed. What the heck, she was the doctor.

Ha! Turns out I had a deep vein thrombosis in the axillary vein in that upper arm! You could have floored me!! I ended up being admitted and given IV heparin drip and oral coumadin. Upon release 3 days later I had to agree to daily blood draws which was a cheap price to pay to be released from the hospital since I didn't feel sick and didnt hurt.

I've since been reading up on STs and DVT and realize my part in letting things go so far. However, I've found quite a bit of controversey on IV phenergan (and also demerol). The Infusion Nurses Society Standard # 43 specifically states phenergan should NOT be given IV due to its PH and potential for harm.

Frankly, given my experience thru the years and the blessing that IV and IM phenergan (and demerol) has been I would hate to see its use be discontinued. However, this was the first and only time phenergan was ever administered IV that close to the IV set instead of up the line where it gets diluted w/the IV fluids.

I'd be interested in your thoughts and experiences on this event and the use and method of administering IV phenergan. Mind you, my mother worked at this hospital all the while I was growing up, other than Mayo Clinic it is the only hospital I have ever gone to (altho we have another in town) and I've been volunteering here for several years in Endoscopy or Messenger Service. I'm not looking to cause any trouble and I know my ER nurse from previous encounters in the cafeteria and elsewhere at the hospital and he is a fine and conscientious nurse. He was marvelous when my brother in law was brought in with an AAA.

i have to say that i have learned a lot reading this thread. phenergan is used at our facility, and in future i will never use it without diluting it. or i'll use an alternative if ordered. i would also like to pursue bringing up the info i've learned here to the appropriate person at my hospital so that we may have better alternatives available.

thanks for the education!

Thank you very much, all of you, for your comments, sympathy and links to further debate on this issue. They are very much appreciated.

It has been long enough I don't remember the size of the syringe for sure but I'm pretty sure it was a 20 cc syringe as I've used 12 ccs at home for tube feeding newborn puppies. If you say toradol should not be given same time as phenergan then I assume he probably pushed the toradol first and I didn't notice until he pushed the phenergan. My memory says it was one syringe and one push but time has passed.

My own personal feelings given previous experience and this experience: go ahead and give me the phenergan IV BUT - give it high up the line with at least 100 cc bag of fluids to dilute it.

Never mind diluting it w/10 ccs of fluid, never mind flushing it w/10 ccs fluids afterwards, don't give it to me except high up the line with a 100 cc or larger bag of fluids.

I give IV phenergan regularly through heplocks/ Even if I'm giving it up the line I dilute it with 10ml of norma saline, then flush after with more saline. All our nurses in our ED do it that way. It's cruel not to.

We give it very often in the ED. Personally, I don't like it because of the pH, but policy changes can be very slow.

Journal of Infusion Nursing - Fulltext: Volume 28(3S) May/June 2005

Infiltration of peripheral catheters is another area of nursing malpractice. ...

Promethazine, an antihistamine, is an irritant and should be diluted in ...

http://www.journalofinfusionnursing.com/pt/re/jinfusionnurse/fulltext.00129804-200505001-00004.htm -

http://www.journalofinfusionnursing.com/pt/re/jinfusionnurse/abstract.00129804-200505001-00004.htm;jsessionid=CrY8e7ydURAsY2jY679Lu7ZXgk2lgpbjEtlJV2Oni64MRoD8j1o1!654213914!-949856032!9001!-1

Specializes in Specializes in L/D, newborn, GYN, LTC, Dialysis.

Can't access that story as I am not a member......I would love to see it.

Hmmm, all it'll take is a nasty case of permanent damage due to phlebitis caused by IV phenergan use, to change policies in more places. It was a few sentinel events that did it for us in our corporation. It's so not worth it. Also: Like pointed out, there are better, newer, and less-sedating/confusion-aggravating drugs out there that are much less likely to do this damage ANYHOW.

Specializes in Med-Surg.
Just thought I would bring a recent experience up for discussion:

29 May I end up in ER w/24 hours of extreme chills (long sleeve T-shirt, PJs, 2 blankets, quilt and down sleeping bag), intermittent, transient bone and joint pain, nausea and vomiting. I was given an IV set near the base of the thumb for fluids and then an IV "push" of phenergan and toradol at the site of the IV set rather than up the line where it would have been somewhat diluted. As a 30 year Crohn's disease patient I have had PLENTY of IV and IM phenergan and demerol w/o any discomfort or problems. But this one BURNED and HURT! The nurse continued the "push" and explained that it was the phenergan. I didn't really believe this given my previous experiences and assumed it was really the toradol as that was my first experience with it. The pain and burning only lasted a few minutes after the "push".

I had no swelling of the hand or arm, no pain, no redness for several days. Long enough that I never even thought of the IV push when I began with a bruised type feeling on the inside of the arm just above the wrist and the outside of the arm 1/2 below the elbow. Several days after that I did notice a hard stretch of vein about 3/4" long 1/2 way below the elbow on the outside of the arm. Later a "bump" at the wrist, still later another 3/4" hard stretch of vein just above and a little to the outside of the bump. And then a 1/2" hard spot in the vein below the base of the thumb at the wrist. It finally occured to me that this was probably the result of the IV push but since there was no redness, no swelling, no tenderness unless I kept poking the areas I didn't bother seeing a doctor about it. (Heaven knows I see him enough as it is, bless his heart!).

21 July the "bump" at the wrist turned red and was tender. Hot compresses did nothing for it that evening nor the next morning. My family doctor isn't in the office on Fridays and I figured the ER IV push was the cause so I went to ER. I was told it was "just" superficial thrombophlebits that could take as much as 6 months to resolve and was about to be released (which was ok with me as long as the doctors weren't concerned). But the "lead" ER doctor came in, first time I had seen her, and she said she would feel more comfortable ordering a venous ultrasound before I was released as she had had 2 STs go "sour" on her in the previous 3 months. I didn't have a problem with that so of course I agreed. What the heck, she was the doctor.

Ha! Turns out I had a deep vein thrombosis in the axillary vein in that upper arm! You could have floored me!! I ended up being admitted and given IV heparin drip and oral coumadin. Upon release 3 days later I had to agree to daily blood draws which was a cheap price to pay to be released from the hospital since I didn't feel sick and didnt hurt.

I've since been reading up on STs and DVT and realize my part in letting things go so far. However, I've found quite a bit of controversey on IV phenergan (and also demerol). The Infusion Nurses Society Standard # 43 specifically states phenergan should NOT be given IV due to its PH and potential for harm.

Frankly, given my experience thru the years and the blessing that IV and IM phenergan (and demerol) has been I would hate to see its use be discontinued. However, this was the first and only time phenergan was ever administered IV that close to the IV set instead of up the line where it gets diluted w/the IV fluids.

I'd be interested in your thoughts and experiences on this event and the use and method of administering IV phenergan. Mind you, my mother worked at this hospital all the while I was growing up, other than Mayo Clinic it is the only hospital I have ever gone to (altho we have another in town) and I've been volunteering here for several years in Endoscopy or Messenger Service. I'm not looking to cause any trouble and I know my ER nurse from previous encounters in the cafeteria and elsewhere at the hospital and he is a fine and conscientious nurse. He was marvelous when my brother in law was brought in with an AAA.

I have given IV phenergan many times. We are "supposed " to dilute the dose with 9 cc's of NSS and push it slow. Our IV pumps are designed to allow us to piggy back the syringe as you would a mini bag and I can set the pump to infuse it as slow as I want and run it continuous with the IV fluids. The nurse should have never pushed phenergan that way at all. That is unbelievable what happened to you. Big lack of education on the nurses part. One of my patients told me that an agency nurse pushed phenergan straight in and didn't do it like I did it and it burned really bad.

I was surprised to learn that toradol is an injectable NSAID. It would seem to me that it would therefore be contraindicated in a patient known to have Crohn's disease. I'm surprised that the ER doctor would have even scripted its one time use for me given my 30 year history of Crohn's. I don't seem to have encountered any problems from that IV injection of it but I don't know that I would be comfortable about letting them give it to me in the future. What are your thoughts on its use in a Crohn's patient?

Phenergan, or Promethazine

Prometheus, the rebel god; in defiance of Zeus, he gave fire and other comforts

to the mortals on the earth.

Now, at least, we know WHY it burns.

heh

For those of you who are diluting Phenergan with 10cc NS, are you documenting this in your notes ?

I work with many Sickle Cell patients and they receive IV Phenergan every 3 hours prn. (along with IV Benedryl, Torodol and sometimes Ativan along with other narcotics for pain and nausea control) We have a policy that states that we MUST dilute Phenergan with 5ml of NS when pushing through fluids or no fluids. I have some pt that must have a hot pack on their arm around the IV site when they receive their Phenergan. What a crazy drug this is. But for some of my patients this is all that works.

Specializes in Emergency, Trauma.

Our hospital policy changed probably about a year ago due to so many cases of irritation/complications with giving it push- now it must be given IVPB in a 50cc bag of NS. I remember as a new nurse seeing it pushed undiluted (by an experienced nurse) through a 22 in the wrist, and immediately the pts vessels were streaking red all the way up the forearm; enough to convince me to never push it undiluted.

As for the toradol, we use it all the time- I don't dilute it. But maybe 1 out of every 15-20 pts do complain of severe burning that's immediately resolved with the saline flush.

Specializes in Telemetry, ICU, Resource Pool, Dialysis.
I was surprised to learn that toradol is an injectable NSAID. It would seem to me that it would therefore be contraindicated in a patient known to have Crohn's disease. I'm surprised that the ER doctor would have even scripted its one time use for me given my 30 year history of Crohn's. I don't seem to have encountered any problems from that IV injection of it but I don't know that I would be comfortable about letting them give it to me in the future. What are your thoughts on its use in a Crohn's patient?

I don't think a one-time dose will cause any problem. The biggest contraindication for Toradol is renal problems. It's never indicated for long term use - we don't use it for any more than 5 days- and using it that long is rare. It's a fantastic pain reliever, though.

My husband had the same reaction to MS given directly into the vein undiluted. His arm looked like those dummy arms we used to start IVs on in school! I've never given phenergan undiluted directly. Always with a flowing IV, or diluted with 5 NS.

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