How much is too much morphine?

Specialties Hospice

Published

I had a patient on hospice last night that was receiving 0.5 mg Lorazepam and 15 mg morphine. The patient began moaning between each breath so we gave her another dose of 0.5 mg Lorazepam and 15 mg of morphine an hour later, as well as repositioned her on her side as she is a bigger lady so the lungs could expand more.

About an hour into my shift this patient continued to moan between each breath, increasing in frequency, so I called Hospice. Hospice said to continue what I was doing every hour and that they would send out a nurse. The nurse came out, evaluated the patient, and decided to continue this 15 mg of morphine every hour and bump up lorazepam to 1 mg every hour (given together diluted in water and placed slowly in the cheek).

I asked the hospice nurse if there was a limit to how much morphine should be administered on my shift, however, the hospice nurse said that the resident needs it. In total I ended up probably giving 120 mg of morphine and approximately 6 mg of lorazepam (8 hour shift). The resident was on comfort cares and has been declining over the past few weeks, and especially has been declining over the past few days. The family was there and accepting of her passing away within the next day or so.

However, at the end of my shift we repositioned the patient went into this anoxic like state while moaning much louder than before. I'm guessing this is a sign of overdose and am concerned that hospice lead me down the wrong path.

Any comments would be great...

Specializes in BNAT instructor, ICU, Hospice,triage.
What is the max dose of morphine?

The amount it takes to make them stop breathing.

The problem when a patient is actively dying is that they are tachypneic. The morphine is to help them slow down their breathing so that they are not feeling like they are running a marathon. So the purpose of the morphine is to help the beta cells in the lungs and help with air hunger. They are dying. They are going to die from the disease NOT the morphine. They are at the very end of their life. I have had a zillion patients on enough morphine for an elephant and they are happily out watering their flowers, and having a quality of life that they would not if it were not for morphine. There is no max dose. The right dose is when the patient is comfortable. We start at the very tiniest dose possible and increase little by little until they are comfortable.

Specializes in Acute Care, Rehab, Palliative.

Yes ortho would be a different matter. We are allowed to push the button for our palliative patients and so can the family. Unless they seem uncomfortable we won't do it unless we are going to have to move them or something that will cause discomfort.

Specializes in Med/Surg, LTACH, LTC, Home Health.
If we know what the person's wishes were, nobody has the right to go against them. If the ethics committee doesn't step up, ADVOCATE.

It's these kinds of stories that make me thankful I don't work in the US. Our system isn't perfect but at least we aren't constantly being threatened with ridiculous law suits.

Your posts about this "scenario" make me incredibly angry. Not *you*, but the whole situation. I'm not a new nurse, I'm not naive, but come on.

Believe me, we were ALL angry at the situation and management's utter disregard of enforcing the advanced directives in place! As soon as my year's contract was up, I was out!! Nobody wanted to be assigned to that particular patient because of the atmosphere of it all. Several physicians were 'fired' from the case by the family. You would expect the medical director would have had something to say about the case but we never heard a whimper from them either. I'm telling you, it was a horrendous experience!

Sad to say, but it was a relief for us on the floor when that poor soul was transferred back to ICU because of the attention that we were forced to give that family when we knew our efforts were in vain, and having 5 other patients is equivalent to a shift from hell. Add that to the nursing students who were forever asking questions even though they were specifically instructed to save all questions until we left the room. As soon as ANYONE began to talk, the family member began taking notes.

One physician went toe to toe with the attorney family member, trying to explain the patient's age, physical condition, etc. Of course, that physician was one of the ones fired from the case. Meetings with case managers and the interdisciplinary team were very frustrating, as they repeatedly said, "our hands are tied; this is what the family wants so we have to honor the 'family's' wishes until the patient can say otherwise". Really????? Yeah, I know...s/he DID say so. Everything was in 'review' clear up until the patient expired.

I feel this case was WORSE than the Terri Schiavo and other well-publicized ethical cases.

Anyway, I know this situation got well off of the OP's post about morphine but this was my most recent experience with morphine and an end-of-life situation. One thing that I didn't mention was that I wasn't the one pushing the Narcan. The primary nurse at that facility does the charting during a code situation so that he/she is available to answer any questions about the patient's medical history as the code is in progress. Still sad, all the same...

As far as the DNR and/or POA, patients trust that their designee will honor their wishes when they cannot speak for themselves. But this does not always happen, as was the case that I witnessed last year with a 97 year old man. It was a sad case and the person was oriented to ALL faculties and was ready to die. But when s/he became incapacitated, his/her designee (who just happened to be married to an attorney), turned the status into a full code. That of course, left us co-workers expecting the ethics committee to chime in at any moment with the right-to-die speech. Well, they NEVER did and 3 months of hospital regimine (labs, bloodwork, vitals, intubation, extubation, 80mg of Lasix today, 20mg of Lasix tomorrow, X-rays.....you name it, it was done), the poor soul finally expired. 97 years old being put through the ringer, and the Ethics Committee did nothing simply because, I believe, an attorney was a member of the immediate family.

Did you happen to know the particular advance directive and the wording in the case of the individual you mention? Perhaps there were details in the case of this person and their family that you were not privy to. Sometimes written words may be interpreted in more than one way.

In the hospital patients would likely be on IV medication. All the dying patients I've cared for in the hospital were on continuous morphine and usually something like versed or ketamine.

UK PCA do not have a basal rate with a basal rate how is this patient controlled?, we use a syringe driver for this to give a basal dose. If we have iv acess we will use if however once this is lost and pt veins are shut down we go the sub cut route. a syringe driver gives a dose over 24 hours and we give bolus doses sub cut as required.

Believe me, we were ALL angry at the situation and management's utter disregard of enforcing the advanced directives in place! As soon as my year's contract was up, I was out!! Nobody wanted to be assigned to that particular patient because of the atmosphere of it all. Several physicians were 'fired' from the case by the family. You would expect the medical director would have had something to say about the case but we never heard a whimper from them either. I'm telling you, it was a horrendous experience!

Sad to say, but it was a relief for us on the floor when that poor soul was transferred back to ICU because of the attention that we were forced to give that family when we knew our efforts were in vain, and having 5 other patients is equivalent to a shift from hell. Add that to the nursing students who were forever asking questions even though they were specifically instructed to save all questions until we left the room. As soon as ANYONE began to talk, the family member began taking notes.

One physician went toe to toe with the attorney family member, trying to explain the patient's age, physical condition, etc. Of course, that physician was one of the ones fired from the case. Meetings with case managers and the interdisciplinary team were very frustrating, as they repeatedly said, "our hands are tied; this is what the family wants so we have to honor the 'family's' wishes until the patient can say otherwise". Really????? Yeah, I know...s/he DID say so. Everything was in 'review' clear up until the patient expired.

I feel this case was WORSE than the Terri Schiavo and other well-publicized ethical cases.

Anyway, I know this situation got well off of the OP's post about morphine but this was my most recent experience with morphine and an end-of-life situation. One thing that I didn't mention was that I wasn't the one pushing the Narcan. The primary nurse at that facility does the charting during a code situation so that he/she is available to answer any questions about the patient's medical history as the code is in progress. Still sad, all the same...

I can't imagine having to deal with that. I feel for you and your coworkers. I also apologize if I came across as angry toward you -- I had a very emotional reaction to your story and I'm sure that came out in my responses.

Back to the original question about how much Morphine is too much. For patients in pain crisis, for cancer patients, for cardiac patients with angina that does not respond to NTG, really, there is no such thing as too much. But, if you continue to have to increase the dosage on the med with little or no relief, then it's also possible the patient needs a different med. Pain receptors (as most of you know) are different for the different types of pain (neuropathic, muscle/tissue/somatic/visceral, bone) AND with age, somatic pain receptors change.

Specializes in ICU.
Did you happen to know the particular advance directive and the wording in the case of the individual you mention? Perhaps there were details in the case of this person and their family that you were not privy to. Sometimes written words may be interpreted in more than one way.

And sometimes family members are just selfish or can't accept the inevitable. Or worse, someone's getting a disability/social security check. I've had several patients who made their wishes VERY well known, and family chose to do something else as soon as the patient was incapacitated.

Specializes in Hospice.

The pt is dying from a terminal disease , not from the morphine. They will die either comfortable with meds are suffer without meds.

Specializes in Hospice.

also there is no ceiling dose for morphine for pt on hospice.

There is NO ceiling dose on morphine. If a pt has been on morphine for a short while his tolerance will increase and the dose will need to increase the dose as well. If you titrate up you will be making the pt comfortable. You can be on 1000 mg of morphine if they have been titrated up long enough. The most deadly dose is the FIRST dose, not the subsequent doses.

Allison BS RN CHPN CM

Specializes in Hospital Education Coordinator.

I recommend you now what your state says about palliative care vs. acute/chronic care.

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