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Discussion

compazine

Has anyone ever had problems with compazine iv? I can't tell the whole story here due to everyone knowing everyone else in this small town and hospital. Thanks in advance.

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I have never given it IV or otherwise. In all the years I have been working I havent ever seen it carried in our pixis. I personally had a dystonic reaction to it after ear surgery taking it PO. it was a awful experience..

Similiar to Mamelle I also had a dystonic reaction to compazine and that was after having received three or four doses earlier. Unlike Mamelle I received it via IV. The solution was to give me Benadryl. Now I have to be very careful about what antiemtics I take. The dystonic reaction was very scary for myself and my parents.

My son had the same reaction.

Other than a dystonic reaction, I've never seen a problem. In all my years I've only seen a handful of those. Easily cured with Benadryl or Cogentin.

My daughter had a severe dystonic reaction on PO. Benadryl was the antidote. Very scary stuff!

I have never given it IV or otherwise. In all the years I have been working I havent ever seen it carried in our pixis. I personally had a dystonic reaction to it after ear surgery taking it PO. it was a awful experience..

In the ER, we seem to give it a lot IM, for back pain. Don't ask me why ... it's an orificenal of meds that one of our docs orders.

It's not ordered much anymore, but when it is ordered I usually give it IV. Sometimes PR, rarely IM. It is available PO by script for home use.

I work Adult Oncology and it's one of the drugs we have on hand. We use it fairly regularly especially when a patient is actively vomiting. It seems to help but can be sedating. We use Zofran, also. I have had a handful of patients who cannot have it. For most it really helps.

My husband had a dystonic reaction to it 4 1/2 hours after he was d/c'd from the ER - Benadryl was the quick fix and it's now listed as one of his allergies to meds - but none the less, I hate giving it to patients because of the fact that it can sometimes take hours for the reaction to take place or you can give them 2, 3 or sometimes 4 doses before they have the reaction.

We rarely give it IM, it's usually IV and most often I pull a Benadryl at the same time and keep it close by to give *just in case*.

Just gave Compazine 10 mg IV two days ago to a patient being prepped for a CT (had to chug Gastrografin).

Absolutely no problems...

it happened to me a few days after also. It was the most bizzare thing ever! I was given cogentin and the symptoms subsided almost immediately. we use alot of zofran and phenergan in the PACU and ER I work in.

so is the dystonic reaction r/t the lowered seizure threshold? Or is it some other reason for this reaction?

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