Case Study: Joint Pain, Rash, Hair Loss - What's Going On?

A new case study in which R.W. presents to her PCP with a cough, mild fever, joint stiffness and pain and a history of rashes, anemia and hair loss. Specialties Critical Case Study

Updated:  

Chief Complaint

R.W. is a married, 34-year-old Hispanic female with two young children who presents to her primary care provider with a productive cough, stiffness and pain in her hands and feet that comes and goes. She states, "It moves around from joint to joint. I'm worried I've got RA like my sister.” Her PCR test for COVID-19 has come back negative.

History of Present Illness

Five years ago, R.W. went to her PCP after four months of rashes that appeared on her arms and legs whenever she went into the sun. She had lost several small patches of hair on her scalp and stated she thought it was related to stress. She also complained of fatigue that required her to take daily naps. She had mild arthritic pain in her fingers and elbows but thought it was related to aging. A tissue biopsy of one of the multiple rash-like lesions from her arm revealed vasculitis (white blood cells within the walls of blood vessels). Her CBC indicated mild anemia, but microscopic examination of a peripheral blood smear revealed that red blood cells were normal in shape size and color, ruling out iron, folate and vitamin B12 deficiencies. A two-month course of prednisone caused all signs and symptoms to resolve.

Past Medical History

Unremarkable, current with all vaccinations including influenza.

Family History

She has two brothers and one sister. Her older sister has rheumatoid arthritis, and an aunt has pernicious anemia. Her mother has Graves' disease.

Social History

No smoking or drinking

Medications

Naproxen for joint pain, antacid for heartburn, no other over the counter drugs

Allergies

NKA

Vital Signs

  • BP 141/90 sitting, RA
  • HR 105
  • RR 20
  • T 100o F
  • HT 5'6"
  • WT 105 lbs

Review of Systems (only abnormal values presented)

  • Skin: Slight jaundice 
  • HEENT: yellowing of the sclera
  • Lungs/Thorax: Auscultation reveals abnormal lung sounds
  • Musculoskeletal: joint stiffness and pain
  • Immune: enlarged axillary and inguinal lymph nodes  

Questions

What is causing the lung symptoms, jaundice, joint stiffness and pain?

What happened 5 years ago?

Imagine you only get 5 questions. What information should you ask for that will give you the most information for a diagnosis?

What labs do you want?

What other diagnostic tests should we run?

Ask me some questions!

Specializes in Oncology, Home Health, Patient Safety.

FINAL ANSWER:

The presence of antinuclear antibodies may mean R.W. has an autoimmune disorder like RA or SLE. Her ANA ratio was 1:640 (someone asked for the complete ANA test result - this is as much information as I am able to give).

The ESR is a blood test that determines the rate at which RBCs settle to the bottom of a tube in an hour. The faster rate seen in R.W. (25) may indicate a systemic disease like lupus. Women under age 50 should have an ESR between 0 and 20.

CBC: results indicate anemia, which is common in lupus. A low WBC or platelet count may occur in lupus as well. The autoimmune attack appears to be focused on her lymphocytes.

  • Hct 23% (females 35-45%)
  • Hgb 11.0 (females 12.0-15.5 g/dL)
  • RBC 3.5 million/mm3 (4.7-6.1)
  • WBC 1,200/mm (4,800-10,800)
    •             75% neutrophils (57-67%)
    •             15% lymphocyte (25-33%)
    •             5% monocytes/macrophages (3-7%)
    •             4% eosinophils (1-4%)
    •             1% basophils (0-1%)
  • Plt 160,000/ mm3

Urinalysis: increased levels of protein or RBCs in urine can occur if lupus has affected the kidneys.

The vasculitis she experienced 5 years ago is another indicator. Vasculitis in lupus results from the trapping of antigen-antibody complexes in blood vessel walls followed by an intense inflammatory response to the immune complexes.

The jaundice may indicate liver involvement. Liver function tests support this (elevated bilirubin, ALT, AST and decreased albumin).

Based upon all the evidence, it is likely that R.W. has Lupus -- a systemic (body wide) autoimmune disease that occurs when the body’s immune system attacks its own tissues and organs. It can affect many different body systems including skin, joints, kidneys, heart, blood forming organs, nervous system and mucous membranes. Lupus is relatively rare (15-124 cases/100,000 people worldwide). Women are affected 10-15x more often than men.

Diagnosis of lupus is aided by the Systemic Lupus Activity Measure- Revised (SLAM-R). The SLAM-R includes 23 clinical manifestations in nine organ/systems and seven laboratory features. Scores range from 0-81. A score of 7 or more is clinically important (for more info: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507322/#:~:text=has been demonstrated.-,Systemic lupus activity measure,basis of domain sampling theory.)

The most common symptoms (I’ve highlighted R.W.s):

  • Low-grade fever
  • Photosensitivity
  • Fatigue
  • Loss of appetite
  • Ulcers of mouth and nose
  • Butterfly rash on face
  • Muscle aches
  • Inflammation of the pleural and cardiac membrane
  • Arthritis in joints
  • Poor circulation in fingers and toes
  • Shortness of breath
  • Chest pain
  • Dry eyes
  • Headaches, confusion and memory loss

Diagnosis: Lupus is difficult to diagnose because the signs and symptoms mimic other diseases. The most distinctive sign is a butterfly rash on the face which occurs in many but not all cases. In addition, no two cases are exactly alike – signs and symptoms can come on suddenly or slowly. They can be mild or severe; temporary or permanent. Most people have mild disease characterized by flare-ups. The combination of blood and urine tests as well as signs and symptoms point to lupus for R.W.

Causes: lupus occurs when your immune system attacks health tissues in your body. It is likely that is results from a combination of genetics and environment. R.W. has several risk factors including gender, age and race. In addition, she has a family history of autoimmune disorders.

Potential environmental triggers include:

  • Exposure to sunlight may trigger skin lesions or an internal response
  • Infection can initiate lupus or cause a relapse
  • Lupus can be triggered by medications like antihypertensives, anti-seizure medications and antibiotics.

Risk factors: Lupus is more common in women, is most often diagnosed between the ages of 15 and 45 and is more common in African American, Hispanics and Asian-Americans.

There is no cure, but treatments can help control symptoms. NSAIDS can treat pain, swelling and fever. Antimalarial drugs can help decrease the risk of lupus flares. Corticosteroids can counter the inflammation but can result in weight gain and increased risk of infection. Immunosuppressants can be helpful in serious cases but side effects can be severe. Biologics like belimumab can reduce symptoms and rituximab can be beneficial with resistant lupus.

Treatment: R.W. was given a 10-day course of antibiotics and placed on prednisone. All signs and symptoms resolved in three months. A few months later she returned to the PCP with fatigue, anorexia, weight loss and significant swelling in the abdomen, face and ankles. She had a butterfly shaped rash on the bridge of her nose and cheeks. Liver function tests revealed liver damage. She decided to enroll in a clinical trial for SLE treatment (for more information: https://www.mayo.edu/research/clinical-trials/cls-20502526)

 

References

4 Votes
Specializes in Education, FP, LNC, Forensics, ED, OB.

Here are the responses from members who came to the Admin Help Desk to submit their diagnoses for the 8th Case Study Investigation (CSI).

?A DOUBLE THUMBS UP to those with the correct FINAL diagnosis!??

TheMoonisMyLantern

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??

I think she has Lupus, her situation just screams inflammation to me and if her ANA comes back positive I would be pretty sure of it. Lupus of course can cause organ damage over time so I wonder if it's effecting her liver thus the sclera yellowing and jaundice. The migratory joint pain also supports a Lupus versus RA presentation. I would have to keep in mind that her ESR may have a false low reading since she is on Naproxen, but I don't believe that effects the ANA. 

Some other differential diagnosis that I thought of were cushings, I strongly considered some type of malignancy as well but I can't reconcile why prednisone would have alleviated her symptoms 5 years ago if her underlying disease process was cancerous.

Any feedback even if I'm wrong would be appreciated. This was a lot of fun!

midwifebetts

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??

This patient has classic signs and symptoms of SLE. The family hx is positive as well as her reported history of symptoms and that she responded to prednisone. 

I would want to get an ANA, ESR, CMP (liver and kidney-jaundice could indicate the lupus is affecting her GI tract), and chest X-ray. A UA might also be helpful. 

RN&run

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?? Is it lupus?

EDNURSE20

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?? Lupus

DowntheRiver

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?? Lupus

evastone

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??

Pretty certain this is Systemic Lupus Erythematosus. Family history of autoimmune disorders puts her at risk. She has some of the classic signs which include joint pain and swelling, sensitivity to sunlight, hair loss, rash. SLE can also present with low grade fevers, anemia, lung and kidney issues.  

It sounds like she's had it for a while too. Five years ago she experienced a Lupus flare up which caused the exacerbation of her symptoms. The corticosteroid she took helped resolve it but it seems that she is having another one. 

Combined with the NSAID, steroids may do the trick again. If not,  antimalarial medication or immunosuppressants may be needed. 

 

 

?COMING SOON: CSI installment #9?

2 Votes

please update us soon! I am suspecting SLE or worsening RA. How about a biopsy of the kidney and liver to rule our SLE? 

I feel like the heart is neglected here. ECHO ?

1 Votes

nevermind I just found it haha. please post more! love these 

2 Votes
Specializes in Public Health, TB.

I just now saw this and was thinking Lupus vs. Wegener's granulomatosis, especially because there was not report of a butterfly rash initially. 

1 Votes

I was thinking lupus! I really enjoyed this case study. Would you check labs more related to lupus specifically to confirm?

1 Votes
Specializes in Oncology, Home Health, Patient Safety.
9 hours ago, MelissaPendergraft said:

I was thinking lupus! I really enjoyed this case study. Would you check labs more related to lupus specifically to confirm?

Like what? The issue with lupus is there are no specific labs that I know of. I’m here to learn as well. Hope I haven’t left something out!

3 Votes

I looked diagnostic labwork up on uptodate 

diagnosis-systemic-lupus.jpg.bd691cc6759aa496f54afb03db5c393c.jpg

1 Votes
Specializes in Oncology, Home Health, Patient Safety.

Excellent- thank you! I so appreciate the knowledge. I’m a generalist, so I really enjoy it when folks who know more than I do chime in.

2 Votes

I absolutely love these case studies. They make me do some deep critical thinking and I learned a lot. I can't wait to find out the answer to see if I was correct

1 Votes
Specializes in Oncology, Home Health, Patient Safety.
5 minutes ago, Txdude254 said:

I absolutely love these case studies. They make me do some deep critical thinking and I learned a lot. I can't wait to find out the answer to see if I was correct

The answer was posted - just scroll back to yesterday to see the response.

1 Votes
Specializes in ED, Tele, MedSurg, ADN, Outpatient, LTC, Peds.

Could not get into admin desk for some reason! Sent a mail to author that it was Lupus!