Case Study: Joint Pain, Rash, Hair Loss - What's Going On?

A new case study in which R.W. presents to her PCP with a cough, mild fever, joint stiffness and pain and a history of rashes, anemia and hair loss.

Updated:  

Chief Complaint

R.W. is a married, 34-year-old Hispanic female with two young children who presents to her primary care provider with a productive cough, stiffness and pain in her hands and feet that comes and goes. She states, "It moves around from joint to joint. I'm worried I've got RA like my sister.” Her PCR test for COVID-19 has come back negative.

History of Present Illness

Five years ago, R.W. went to her PCP after four months of rashes that appeared on her arms and legs whenever she went into the sun. She had lost several small patches of hair on her scalp and stated she thought it was related to stress. She also complained of fatigue that required her to take daily naps. She had mild arthritic pain in her fingers and elbows but thought it was related to aging. A tissue biopsy of one of the multiple rash-like lesions from her arm revealed vasculitis (white blood cells within the walls of blood vessels). Her CBC indicated mild anemia, but microscopic examination of a peripheral blood smear revealed that red blood cells were normal in shape size and color, ruling out iron, folate and vitamin B12 deficiencies. A two-month course of prednisone caused all signs and symptoms to resolve.

Past Medical History

Unremarkable, current with all vaccinations including influenza.

Family History

She has two brothers and one sister. Her older sister has rheumatoid arthritis, and an aunt has pernicious anemia. Her mother has Graves' disease.

Social History

No smoking or drinking

Medications

Naproxen for joint pain, antacid for heartburn, no other over the counter drugs

Allergies

NKA

Vital Signs

  • BP 141/90 sitting, RA
  • HR 105
  • RR 20
  • T 100o F
  • HT 5'6"
  • WT 105 lbs

Review of Systems (only abnormal values presented)

  • Skin: Slight jaundice 
  • HEENT: yellowing of the sclera
  • Lungs/Thorax: Auscultation reveals abnormal lung sounds
  • Musculoskeletal: joint stiffness and pain
  • Immune: enlarged axillary and inguinal lymph nodes  

Questions

What is causing the lung symptoms, jaundice, joint stiffness and pain?

What happened 5 years ago?

Imagine you only get 5 questions. What information should you ask for that will give you the most information for a diagnosis?

What labs do you want?

What other diagnostic tests should we run?

Ask me some questions!

OK, do the revelation now.  I've been waiting long enough.  

7 minutes ago, Kooky Korky said:

OK, do the revelation now.  I've been waiting long enough.  

The lab and diagnostic results haven’t been revealed yet, there isn’t enough information yet. 

Specializes in Education, Informatics, Patient Safety.

First official follow up post (I've summarized some of my responses to your questions):

The patient has been married for 10 years to the same man, prior to that two partners-no history of STDs. She sells real estate for a large real estate company. Weight at most recent annual doctor’s visit 8 months ago: 120 lbs. No travel outside US

  • Antinuclear antibody test (ANA): positive
  • ESR: 25 mm/hr
  • Chest X-ray: mild pulmonary edema with no white blood cell infiltrates in the terminal airways

The PCP is thinking bronchitis but is worried about the development of pneumonia.

R.W. asks, “So do you think I have RA?”

 

Urinalysis: abnormal protein concentration with significant red and white blood cells. A 24-hour urine protein revealed excretion of 2.5 g protein in 24 hr. Elevated blood urea nitrogen (21 mg/dL), and elevated creatinine (2 mg/dL)

  • CMP: WNL
  • Thyroid panel: WNL
  • Liver panel: AST 42 U/L; ALT 60 U/L; bilirubin 1.1 mg/dL, Albumin 3.0 g/dL
  • Glucose: WNL

CBC

  • Hct 23%
  • Hgb 11.0
  • RBC 3.5 million/mm3
  • WBC 1,200/mm
    •             75% neutrophils
    •             15% lymphocyte
    •             5% monocytes/macrophages
    •             4% eosinophils
    •             1% basophils
  • Plt 160,000/ mm3

I will post the final result on Tuesday! Thanks for your patience:)

Specializes in Education, Informatics, Patient Safety.
11 hours ago, CommunityRNBSN said:

I hate all these case studies because they make me feel like a complete idiot. ?

Oh! please don't feel that way! I get it, but seriously - this is supposed to be a fun way to learn. Feel free to Google symptoms. Our hope at allnurses is that you become better at spotting worrisome symptoms.

Specializes in in primary care pediatrics and NICU.

in ROS, Pt complaints of Raynaud's phenomenon? just curious. 

Specializes in Education, Informatics, Patient Safety.
4 minutes ago, Babyboss 19 said:

in ROS, Pt complaints of Raynaud's phenomenon? just curious. 

No, but that’s an excellent question- you’re on the right track

Did she have a butterfly facial rash or a different type of rash?

Specializes in CEN.

Definitely want to do an ANA. PT/PTT, INR. I see a skin biopsy was done, maybe consider a kidney biopsy as well?

Has she had nose or mouth sores?

Any chest pain with deep inspiration?

Specializes in Education, Informatics, Patient Safety.
11 hours ago, Carolyn Hull Walker said:

Did she have a butterfly facial rash or a different type of rash?

No butterfly rash 

8 hours ago, evastone said:

Definitely want to do an ANA. PT/PTT, INR. I see a skin biopsy was done, maybe consider a kidney biopsy as well?

Has she had nose or mouth sores?

Any chest pain with deep inspiration?

Please see my previous post for results of ANA and CBC. No nose or mouth sores, no chest pain with deep inspiration.

I'd like to see the full results of the ANA panel.

Specializes in Palliative and Hospice.

Any history of tic bites? Get Lymes Disease panel drawn either way.

Specializes in ER.

Was an ELISA and CRP done? What does or did skin rash look like and where was it and how a long ago did she notice it? To start with.