toomuchbaloney 10,803 Posts Specializes in NICU, PICU, Transport, L&D, Hospice. Has 44 years experience. Sep 5, 2022 28 minutes ago, Davey Do said: Empirical knowledge is that information which is gained by direct observation. For example, antipsychotics act as dopamine antagonists in order to abate the inappropriate behavior in patients diagnosed with schizophrenia. This basically means that the excessive dopamine secreted by the presynaptic cleft in the neuron is not received by the receptor in the post synaptic cleft. The inappropriate behavior is decreased due to the interruption of the electrical chemical process in the brain. This information was not learned empirically, it was learned through reading and discussion, and was accepted because it was logical. Never having seen a neurotransmitter or synaptic cleft, the information is accepted purely on the basis that it makes sense and was not gained empirically. Is that information that you feel is generally shared with patients by nurses?