I worked full time and raised my kids as a single parent, graduated with a 4.0. Like another poster pointed out, difficult is a relative term. Some of my classsmates 20+ years ago swore it was the hardest thing ever. Others, like me, just rolled with it and did the best we could.
1 of the techs at my clinic states that it's so hard (just the prereqs), but she's online gaming with her friends a lot of the time, constantly going out, and doesn't like to study, and can't understand why she's failing (she's failed all prereqs at least once), but she knows that she's a shoe in for nursing school and she's going to set them straight on how they teach. I have a hard time being supportive, but I at least don't make negative comments.
For some it will be hard, for others not so much. It's like anything else, it's what you make of it.