Secretion of cortisol and anti-inflammatory drugs???

  1. I am trying to find the answer for question " Does taking too much anti-inflammatory drugs( like ibuprofen) have an effect of secretion cortisol by anterior pituitary gland?" This question we were asked on our AP class. I tried to find something on Google but with no effect.
    Does anyone know website where I can find more about this topic?

    I read information about ibuprofen in Nursing Drug Handbook. I read carefully precautions and interactions as well, but I didn't found anything that would be influencing levels of cortisol in the bloodstream, or any connections with the disorders resulting from different cortisol levels.

    Thank you for any help!
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    About Miss_Piggy.RN

    Joined: May '08; Posts: 201; Likes: 61
    Registered Nurse; from US

    10 Comments

  3. by   OrlandoFLNurse2b
    This is just me working through it without the aid of my pharm book, but cortisol is released during times of both psycho- and physiological stress so if an anti-inflammatory is reducing inflammation (indirectly reducing both types of stress) then indirectly it would reduce cortisol levels by reducing the demand for it. I don't think it reduces it via classic negative feedback loop (that may be what your instructor is looking for in this question). Basically, I don't think this answer is a simple yes or no. There are some awesome nurses on this board with a wonderful pharm understanding so hopefully another one will reply.
  4. by   Vito Andolini
    Why not consult the experts - pharmacists. Let us know the answer, please.

    BTW, what does your teacher say?
  5. by   nminodob
    Just off the top of my head I would say it has a minimal effect - my logic being, that drugs that directly affect the release of cortisol like steroids have to be tapered so the person doesn't go into an Addisonian crisis - too little hormone being secreted because of exogenous replacement. I have never heard of this occurring even with long-term NSAID use, so I believe it can't interfere with the feedback loop that controls cortisol. Let's see what the experts on the board think!
  6. by   morte
    Quote from yennefer
    I am trying to find the answer for question " Does taking too much anti-inflammatory drugs( like ibuprofen) have an effect of secretion cortisol by anterior pituitary gland?" This question we were asked on our AP class. I tried to find something on Google but with no effect.
    Does anyone know website where I can find more about this topic?

    I read information about ibuprofen in Nursing Drug Handbook. I read carefully precautions and interactions as well, but I didn't found anything that would be influencing levels of cortisol in the bloodstream, or any connections with the disorders resulting from different cortisol levels.

    Thank you for any help!
    try PubMed......i found a few things that might apply.....when i tried to link, i screwed up.....so give it a shot good luck
  7. by   Miss_Piggy.RN
    Vito Andolini she didn't know the answer for this question that is why she gave as homework to do some research about this topic.
  8. by   Vito Andolini
    Quote from yennefer
    Vito Andolini she didn't know the answer for this question that is why she gave as homework to do some research about this topic.
    Oh, I see. Have you had any luck? I still think a pharmacist is your best resource. Is there a pharmacy school near you?

    Surely, a reference librarian can help track down this answer.

    Let us know.
  9. by   ERjodiRN
    this is a good question. as an otc drug, i can't believe that it directly has that big of an impact on cortisol secretion. i do believe that they have used ibuprofen and other nsaids to help treat orthostatic hypotension that you get with things like addisonian crisis, etc.
  10. by   leslie :-D
    Quote from yennefer
    I am trying to find the answer for question " Does taking too much anti-inflammatory drugs( like ibuprofen) have an effect of secretion cortisol by anterior pituitary gland?" This question we were asked on our AP class. I tried to find something on Google but with no effect.
    yennefer honey, i think you're misreading the question.

    corticosteroids, produced by the adrenal glands, are secreted in response to stressors, such as illness and/or injury:
    inflammation, and assist in the immune response.
    they are a natural anti-inflammatory (think of prednisone, cortisone, etc).
    nothing to do with ibuprofen, but more of the role of the corticosteroids produced in our very own bodies.

    does that help in making the connections?

    leslie

    eta: maybe i am misreading the question...
    did the teacher specifically mention cortisol release from the pituitary?
    if so, levels would increase in response to the stress response.
  11. by   leslie :-D
    oy....:yldhdbng:

    do not mind me...
    worked last noc and haven't slept yet.
    nevermind.
    scratch that.
    my bad...

    leslie
  12. by   UM Review RN
    Thread moved to Nursing Student Assistance forums for more answers.

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