Drugs and their Antidotes!!!

  1. 9 I hope this will help us! If you can find some errors, I would very much appreciate any corrections.

    Drugs and Their Antidotes

    1. acetaminophen - acetylcycteine
    2. benzodiazepine - flumazenil
    3. coumadin - vitamin k
    4. curare - tensilon
    5. cyanide poisoning - methylene blue
    6. digitalis - digibind
    7. ethylene poisoning - antizol
    8. heparin - protamine sulfate
    9. iron - desferal
    10. lead - edetate disodium (edta), dimercaprol (bal), succimer (chemet)
    11. lovenox - protamin sulfate
    12. magnesium sulfate - calcium gluconate
    13. morphine sulfate - naloxone hydrochloride
    14. methotrexate - leucovorine
    15. mestinon - atropine sulfate
    16. neostigmine - pralidoxime chloride (pam)
    17. penicillin - epinephrine
    18. vincristine (oncovin) - hyaluronidase,also apply moderate heat to disperse drug and minimize sloughing. (oncovin - iv administration only)

    Poison Antidotes

    arsenic---------------------------------------------------------------dimercaprol, succimer
    barbiturates(phenobarbital)---------------------------------urine alkalinization, dialysis, activated charcoal
    caffeine, metaproterenol, theophylline------------------esmolol
    carbon monoxide------------------------------------------------100% oxygen, hyperbaric o2
    cholinesterase inhibitors--------------------------------------atropine
    cyanide---------------------------------------------------------------nitrite, sodium thiosulfate
    ethylene glycol-----------------------------------------------------ethanol
    heparin---------------------------------------------------------------protamine sulfate
    iron salts-------------------------------------------------------------deferoxamine
    isoniazid--------------------------------------------------------------vitamin b6

    lead--------------------------------------------------------------------caedta, dimecaprol, succimer
    methanol------------------------------------------------------------ethanol, fomepizole, dialysis
    methemoglobin/cyanide poisoning------------------------methylene blue
    muscarinic receptor blockers---------------------------------physostigmine
    organophosphate cholinesterase inhibitors------------pralidoxime
    phencyclidine hydrochloride(pcp)--------------------------ng suction
    quinidine, tca's-----------------------------------------------------sodium bicarbonate
    salicylates------------------------------------------------------------urine alkalinization,dialysis, activated charcoal
    snake bites----------------------------------------------------------antivenin
    tissue plasmogen activator (tpa), streptokinase-------aminocaproic acid
    warfarin---------------------------------------------------------------vitamin k, ffp
    Do you have some additional info????? pls share it! thanks! :typing

    God bless!!!
    Last edit by Joe V on Mar 28, '18 : Reason: formatting
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    About joycee8

    Joined: Jul '09; Posts: 161; Likes: 57
    from AZ , US


  3. by   splintersurgeon
    #1 1
    lovenox has no antidote . penicllin has no antidote . allergies , you can give epinephrine
  4. by   joycee8
    #2 0
    ohh! really? thanks for that info splintersurgeon. so i guess my source right now is mistake, but lovenox is anticoagulant like heparin???

    i remember during our pharma class that if a patient has anaphylactic shock then must need epinephrine, and our book and clinical instructor says that also, infact it's one of the question in our test, i've got it right. then my source right now, said that epinephrine is the antidote of penicillin, i just figure out maybe because anaphylactic shock is a common side effect of penicillin. Does this make sense???
  5. by   hypocaffeinemia
    #3 0
    Epinephrine isn't an antidote in the traditional sense of the term. It's a therapy modality for anaphylaxis (which could be due to any drug).
  6. by   splintersurgeon
    #4 0
    actually penillicillin , and its derivatives including cephalosporins , their common side effect is allergy or anaphylaxis. anaphylactic shock is one severe form of allergy. low molecular weight heparin like lovenox dont need an antidote since its milder form compared to the unfractionated heparin . my sources NCSBN learningext and pharmacology by Goodman. I can vouch for it - i am also a surgeon from another country
  7. by   joycee8
    #5 0
    ok, now i understand! hehehe! thanks for the good input DR..... i graduated my nursing school from other country too. GOD BLESS!
  8. by   splintersurgeon
    #6 2
    Good luck in your exam . God bless . dont be intimidated by the exam , you can do it . anything ur not sure of , verify always . remember you can always reschedule if ur not ready
  9. by   nclexRNtaker
    #7 0
    So I'm a self proclaimed pharm dork.. Anyone up for a quick review?

    What're the antidotes/drug of choice for the following?

    Iron toxicity?
    Lead toxicity?
    Extrapyramidal Syndrome?
    Neuroleptic Malignant Syndrome?
  10. by   yellowflowers
    #8 1
    iron -deferoxamine
    lead-chelating agent
    heparin- protamin sulfate
    cumadin- vit k
    digoxine-digoxine immune fab
  11. by   nclexRNtaker
    #9 1
    Iron toxicity? - Desferal Mesylate
    Lead toxicity? - EDTA
    Heparin? - Protamine Sulfate
    Coumadin? - Vitamin K
    Digoxin? - Digibind
    Narcs? - Narcan
    Benzos? - Romazicon
    Atropine? - Physostigmine Salicylate
    Thrombolytics? - Amino Caproic Acid
    Extrapyramidal Syndrome? - Cogentin/Artane
    Neuroleptic Malignant Syndrome? - Dantrolene/Parlodel
  12. by   caliotter3
    #10 0
    Thanks, this is a good review.
  13. by   SEDK
    #11 1
    Actually, and I know this is old but I teach nursing and hate to see information that's incorrect, but Protamine is used to neutralize Lovenox. Always check your sources and information. Including your sources sources if needed. It doesn't matter if they're a doctor from the US, another country, or another planet, you need to be sure because it's your practice and not theirs. Think if it this way, you're sitting in court, your patient bled to death and the attorney says you didn't know protamine sulfate was the antidote? You say, "well I thought I did but this dr. from another country online told me it wasn't". I'm sure since this post is so old you've come a long way in your practice. I still wanted to put it out there so other new nurses may benefit.SarahPer the Cleaveland clinic it's 1mg of Protamine SIVP for 1 mg of Lovenox. See here:Page Not Found - Cleveland Clinic Center for Continuing Education RXmed:http://www.rxmed.com/b.main/b2.pharm...OVENOX.htmlFor treatment of overdose:Protamine (either the sulphate or hydrochloride salt) should be administered in more serious cases. The anticoagulant effect of the drug is inhibited by protamine. A slow i.v. injection of protamine will almost completely neutralize the anticoagulant activity of enoxaparin (i.e., the anti-IIa activity); however, the anti-Xa activity is only partially neutralized (maximum about 60%). The dose of protamine should be identical to the dose of enoxaparin injected, that is, 1 mg or 100 units of protamine to neutralize the anti-IIa activity generated by 1 mg enoxaparin. Particular care should be taken to avoid overdosage with protamine. The half-life of enoxaparin should be taken into account when calculating the neutralizing dose of protamine to avoid overdosage. The rate of administration of protamine should not exceed 50 mg in any 10-minute period since administration that is too rapid can cause severe hypotensive and anaphylactoid-like reactions.
  14. by   Assess&Safety1st
    #12 0
    hello everyone,
    can someone give me information on drugs and their antidotes?
    i have a few but would like to know the most used drugs in hospital or common in nclex i might see or need to be aware of.
    i'm about to take my nclex pn and asking for any help.

    thank you in advance

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