The Moderna and Pfizer vaccines use nanoparticle encapsulation to protect the mRNA enclosed in the vaccines until it can get into the immune system. There have been some concerns about the lipid nanoparticles containing components to which some people are reacting to with anaphylaxis, and other adverse reactions. Below is an excerpt of an article that discusses the lipid nanoparticle, and also a link to the article I found it in, which is interesting, as it also discusses the stability of the mRNA vaccine:
In a rapid response posted on bmj.com, JW Ulm, a gene therapy specialist who has published on tissue targeting of therapeutic vectors,13 raised concerns about the biodistribution of LNPs: “At present, relatively little has been reported on the tissue localisation of the LNPs used to encase the SARS-CoV-2 spike protein-encoding messenger RNA, and it is vital to have more specific information on precisely where the liposomal nanoparticles are going after injection.”14
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17 minutes ago, underpressure said:
As you like to say, that's your opinion. I don't need to justify anything.
OK
You are the one who started the thread and discussion. You don't have to justify your beliefs and that is a good thing since the justification so far seems rooted in unfounded fears.
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37 minutes ago, litepath2 said:
mRNA makes some really big claims. And all the while (>10 yrs.) they've accomplish exactly zilch IMO.
Maybe my Google-fu is weak, but I don't recall ever seeing an mRNA therapeutic that has ever been approved by the FDA.
It's interesting that you aren't impressed with how quickly the technology could provide safe and effective vaccines in the middle of a terrible pandemic. It's interesting that the covid vaccines represent zilch to you.
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mRNA technology has been studied for approximately 10 years, especially for cancer medication delivery. That's why mRNA was able to be quickly shifted to COVID vaccination development and use.
...Moreover, lipid-based nanosystems offer several indirect-ways to address drug-resistance issues, by one or more of the following strategies:
• Achieving a sustained release profile of the drug, to maintain steady concentrations within its therapeutic concentration, and thus avoiding suboptimal levels which can promote resistant microbes selection (Nafee et al., 2014; Chetoni et al., 2016).
• Lowering the drug toxicity by encapsulation, allowing higher doses and/or treatment periods (Severino et al., 2015; Chaves et al., 2018).
• Increasing systemic BA (Chetoni et al., 2016; Banerjee et al., 2020) and CNS levels (Abdel Hady et al., 2020).
• Allowing pulmonary administration, with less unspecific distribution (Nafee et al., 2014; Gaspar et al., 2016, 2017; Maretti et al., 2017; Vieira et al., 2018).
• Promoting accumulation in target cells by means of active targeting (Maretti et al., 2017; Costa et al., 2018; Vieira et al., 2018; Hosseini et al., 2019; Banerjee et al., 2020).
• Increasing inhibitory effect (I.e., decreasing MIC) over bacterial strains (Severino et al., 2015; Pignatello et al., 2017; Ghaderkhani et al., 2019; Rodenak-Kladniew et al., 2019).
Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform for the development of novel effective cancer immunotherapies. Advances in non-viral gene delivery technologies, especially the tremendous progress in lipid nanoparticles' manufacturing, have made possible the implementation of mRNA-based antitumor treatments. Several mRNA-based immunotherapies have demonstrated antitumor effect in preclinical and clinical studies, and marked successes have been achieved most notably by its implementation in therapeutic vaccines, cytokines therapies, checkpoint blockade and chimeric antigen receptor (CAR) cell therapy. In this review, we summarize recent advances in the development of lipid nanoparticles for mRNA-based immunotherapies and their applications in cancer treatment. Finally, we also highlight the variety of immunotherapeutic approaches through mRNA delivery and discuss the main factors affecting transfection efficiency and tropism of mRNA-loaded lipid nanoparticles in vivo.
The mRNA vaccines represent a remarkable and promising technology, with potential to expedite the development of immunization protocols for future epidemics, but this promise will evaporate if unanticipated safety issues and side effects emerge to weaken public trust in the new modality.
Important point in that post. Why did we not bring the PRISM program back and instead are using VAERS?
PRISM was built and designed for this very thing. To inspire confidence in vaccine safety (H1N1). One of the key ways it did this was to have members removed from the profit chain.
"The National Vaccine Program Office convened an independent group of experts — and by that we mean independent from vaccination program purchasing, distribution, and promotion, as well as independent from conflicts of interest — to conduct rapid reviews of the available safety data. They were solely responsible for looking at the safety of the vaccine, not its benefits. The safety data were presented to this group every two weeks, and it publicly discussed its reports once a month."
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2 hours ago, litepath2 said:
Important point in that post. Why did we not bring the PRISM program back and instead are using VAERS?
PRISM was built and designed for this very thing. To inspire confidence in vaccine safety (H1N1). One of the key ways it did this was to have members removed from the profit chain.
"The National Vaccine Program Office convened an independent group of experts — and by that we mean independent from vaccination program purchasing, distribution, and promotion, as well as independent from conflicts of interest — to conduct rapid reviews of the available safety data. They were solely responsible for looking at the safety of the vaccine, not its benefits. The safety data were presented to this group every two weeks, and it publicly discussed its reports once a month."
Can I ask? Why reply if you can't present an argument to my statement/s and instead choose to interject/proselytize about my taking a vaccine? My vaccine status is not germane to the discourse. And my argument is valid.
PRISM is indeed what I said it was and it is not Online for COVID.
We have this COVID pandemic. And there are a lot of people that are refusing to take the vaccine. My argument above on the PRISM project is directly R/T this issue. Vaccine proponents can nay-say and spit all they want, but there is a problem and it will not be cured by shaming, yelling or IMO anything other than reason.
Right about now we need to take a good look into our collective toolboxes.
Specializes in NICU, PICU, Transport, L&D, Hospice.
12 minutes ago, litepath2 said:
Can I ask? Why reply if you can't present an argument to my statement/s and instead choose to interject/proselytize about my taking a vaccine? My vaccine status is not germane to the discourse. And my argument is valid.
PRISM is indeed what I said it was and it is not Online for COVID.
We have this COVID pandemic. And there are a lot of people that are refusing to take the vaccine. My argument above on the PRISM project is directly R/T this issue. Vaccine proponents can nay-say and spit all they want, but there is a problem and it will not be cured by shaming, yelling or IMO anything other than reason.
Right about now we need to take a good look into our collective toolboxes.
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As you like to say, that's your opinion. I don't need to justify anything.