Differential Case Study: Lyme Disease or Covid-19?

Lakeith, a 35-year-old black man living in New York State, presents with a fever of 101 degrees F. He is concerned he might have contracted Covid-19. Based upon a true story, this case study highlights the need to be aware of life-threatening diseases that can masquerade as Covid-19. Specialties Critical Case Study

Updated:  

Chief Complaint

Fever of 101o F, fatigue and lethargy, stiff neck and jaw, chills and sweating with fever, muscle aches and pains with fever. "I feel like I have the flu. I'm worried I might have Covid-19.”

History of Present Illness

Lakeith awoke on Saturday morning feeling exhausted. As the morning progressed, he began to have aches and pains. He took an oral temperature that was 101o F. His first thought was that he had contracted Covid-19. He is a home health physical therapist who specializes in geriatric physical therapy. He sees four to five patients each day. Several of his patients have tested positive for Covid-19. When working with any of his patients, Lakeith wears an N-95 mask and gloves and practices strict hand hygiene.

Before calling his primary care provider, Lakeith went online and took the Mayo Clinic Covid-19 Self-Assessment Tool to see if his symptoms fit with those for Covid-19.

Here are the questions with his response

  • Have you been within 6 feet of a person with a lab-confirmed case of COVID-19 for at least 5 minutes, or had direct contact with their mucus or saliva, in the past 14 days? YES
  • Does the person with COVID-19 live with you? NO
  • In the last 48 hours, have you had any of the following NEW symptoms? Check all that apply.
Response Symptom
Yes Fever of 100 F (37.8 C) or above
Yes Fever symptoms like alternating chills and sweating
No Cough
No Trouble breathing, shortness of breath or severe wheezing
Yes Chills or repeated shaking with chills
Yes Muscle aches
No Sore throat
No Loss of smell or taste, or a change in taste
No Nausea, vomiting or diarrhea
Yes Headache
No None of the above
  • Do you have any of the following possible emergency symptoms? Check all that apply.
Response Emergency Symptom
No Struggling to breathe or fighting for breath even while inactive or when resting
No Feeling about to collapse every time you stand or sit up (floppiness or a lack of response in a child under age 2)
No None of the above
  • Is the person with a fever younger than 3 months old? NO
  • Have you traveled in the past 14 days to regions affected by COVID-19? NO
  • Do you live in a care facility? NO
  • Do you work in healthcare? YES

After taking the test, he called his primary care office and the triage nurse directed him to come in for a Covid-19 test.

General appearance

The patient arrived at clinic for a Covid-19 test wearing a mask, shoulders drooping, eyes heavy-lidded. Speech is slow and measured. While the nurse prepped for the test, she noticed the patient repeatedly attempting to scratch his back.

Past Medical History

Uncomplicated appendicitis at age 12

Family History

Father, age 56, and mother, age 52 both have HTN and hypercholesterolemia. Thirty-three-year-old sister with obesity and type 2 diabetes.

Social History

Occasional marijuana use, drinks alcohol 1-2 times weekly. Non-smoker. Lives alone. Patient has a girlfriend of three years. He has been socially isolating since March 15th due to his high-risk job.

Medications

Takes Tylenol or ibuprofen for aches and pains. Daily Allegra for seasonal allergies.

Allergies

NKA

This case study is different from others in that I am letting you know from the start that Lakeith has Lyme disease, Covid-19 or both.

What information do you need to determine his diagnosis? He's had a nasal swab for Covid-19, but the results won't be available for another three days.
What else would you check before he leaves the primary care clinic?

References

Merck Manual Professional Edition: Lyme Disease

Specializes in ICU, LTACH, Internal Medicine.

From the provider point of view:

1). Ddx question in this situation is principally nil and zero, because right now every patient is basically treated like COVID19 patient until proven otherwise.

It is not written if the patient came to urgent care, ER or primary care office, but with fever and aches and direct contact with people of increased risk he will be sent to testing place at once, and so the question about COVID19 will therefore be solved. It is not necessary to think about it or follow absurd protocols and checklists (by common sense anyone who visit any place with more than himself around cannot for all honesty say that he absolutely was not near anyone who had confirmed COVID unless everyone around him was tested negative and it is known). It is just necessary to recognize one simple fact of today: not confirmed "negative" = "positive" unless proven not by DOUBLE test PCR (antibodies are optional and possibly useless at the beginning of the process).

Once we answered the question about the COVID, we can proceed with further differential, which is a little wider than just Lime. And we are not forgetting that one can have COVID19 and Lime disease at the same time.

2) from answers: some of them illustrate very common mistake, particularly characteristic for nursing providers: ordering every test and the kitchen sink, at once, basing on some bits and pieces. It illustrates the classic American nursing way of thinking of "doing something for something".

Routine tests such as lipid profile, TSH or iron profile should NEVER be ordered in the middle of acute infectious process, trauma, severe acute exacerbation of chronic disease, in immediate postop period, etc. unless there is a compelling evidence of need to test such as well-based differential. A human being in acute period of infection is different from the same human being after recovery, in metabolic point of view. Doing otherwise leads to diagnostic mistakes and, eventually, harm. Assuming you got cholesterol of 275 on this patient. He is in acute stage of infection and already has muscle pains. He might have already, or develop soon, mild transaminitis. We may have to use quite a bit of Tylenol and other hepatotoxic meds on him. Do you really want add statin on top of this mess? If not, why spend $$ for inherently useless testing which can be safely performed later?

3). Again, line of thinking characteristic for nursing providers in particular: one big thing or no thing. Bull's eye =>> Lime disease, stop at that. Without even checking the total body surface. With the patient being 35 years old male, our differential must include syphilis (at secondary stage, it can produce skin rashes looking amazingly like bull's eyes) and several other common skin conditions like erythema multiforme, by a short list.

Overall, not a good example of clinical question. Sorry. But at least an attempt.

Specializes in Telemetry, DD, Ortho, CCU, BHU.

COVID-negative. COVID -19 is so new and there is so much more to learn. There have been people who have tested positive detection, quarantined and then show negative detection and then positive detection again. We have so much more to learn about this virus and possible mutations.
Would wait for lab results Elisa, Western Blott before saying Lyme disease is positive although there is an overwhelming evidence without blood work that indicates it is Lyme disease. VegRNmom mentioned that the Lyme disease test is not reliable. I have to agree with that. So I would treat for Lyme disease.

Prophylactic Doxycycline 100mg BID order by Physician should be started and continued for a full treatment of 2 weeks should the Lyme disease be detected or not.

Specializes in Oncology, Home Health, Patient Safety.

Sorry I didn't post the final results sooner, but I seem to have some kind of infection...folks, it’s getting weird over here. Over the weekend I developed the exact same symptoms I described in Lakeith (fever, aches and pains, chills, headache). I had a tick bite 2 weeks ago, though no bulls eye rash. I just got tested for Covid-19 this morning at an urgent care clinic, and I’m waiting to hear back from my primary care provider (apparently, they don’t call you back the same day anymore!) I’ll keep you posted on my case, but in the meantime:

Lakeith’s Lab values:

  • ALT 150 (normal is 7-55 U/L)
  • AST 105 (normal is 8-48 U/L)
  • Bilirubin 3.5 (normal 0.1 to 1.2 mg/dL)
  • All other blood work was normal

Elevated liver enzymes are common in both Covid-19 and Lyme disease, so this isn’t a good differential. A study I read showed 76.3% of 417 patients had abnormal LFTs and 21.5% had liver injury with Covid-19 (April 13, 2020, https://www.journal-of-hepatology.eu/article/S0168-8278(20)30218-X/fulltext). They had ALT, AST, total bilirubin and gamma-glutamyl transferase levels elevated to more than 3× the upper limit. Patients with abnormal liver tests of hepatocellular type or mixed type at admission had higher odds of progressing to severe disease

For practical and efficient screening of large populations for a viral infection like Covid-19, reports from China recommend including white blood cells (WBC) and C-reactive protein (CRP) in laboratory examinations for early monitoring of infection (Lu, L. Interpretation of 7th edition of COVID-19 diagnostic and treatment guidelines. Lifotronic webinar: Diagnosis Guidelines for COVID-19, March 19, 2020 https://onlinelibrary.wiley.com/doi/10.1002/ajh.25774)

Their analysis revealed that on admission (so this would be for patients much sicker than Lakeith), most patients had a normal CBC (normal Hb, WBC and platelet count) and lactate dehydrogenase (LDH). And, no patient presented with moderate or severe thrombocytopenia that is frequently observed in other viral illnesses such as dengue fever.

However, reports from China are showing high levels of lymphopenia (Absolute Lymphocyte Count < 1 × 109/L). Those requiring ICU care had a lower ALC and higher LDH. Lymphopenia (ALC) and lactate dehydrogenase (LDH) have both been significantly elevated in hospitalized COVID-19 patients in a small study of 96 confirmed COVID-19 cases in Singapore.

Lyme Disease

In the U.S., Lyme disease is caused by Borrelia burgdorferi and Borrelia mayonii. The most common tick-borne illness, Lyme disease is transmitted by the bite of an infected deer tick.

Lakeith’s nurse practitioner ordered an ELISA test for Lyme, though an ELISA test might not be positive during the early stage of Lyme disease. The rash is distinctive enough to make the diagnosis without further testing in people who live in areas infested with ticks that transmit Lyme disease (New York State is a hot spot for Lyme disease). In addition, the ELISA test can sometimes provide false-positive results, so it’s not the sole basis for diagnosis. Lakeith’s ELISA and subsequent Western blot both came back positive.

Signs and Symptoms of Lyme

A small, red bump, similar to the bump of a mosquito bite, may appear at the site of a tick bite or tick removal, but this may occur with or without Lyme disease. Erythema migrans (bullseye rash) is one of the hallmarks of Lyme disease, although not everyone with Lyme disease develops the rash. Other symptoms include Fever, chills, fatigue, body aches, headache, neck stiffness and swollen lymph nodes. If untreated, new signs and symptoms of Lyme infection might appear in the following weeks to months (https://www.CDC.gov/lyme/signs_symptoms/index.html). These include bouts of severe joint pain and swelling, especially likely to affect the knees, but the pain can shift from one joint to another. Weeks, months or even years after infection, meningitis can cause Bell's palsy, numbness or weakness in limbs, impaired muscle movement and problems with mentation and memory, so it is important to diagnose Lyme early. Delayed diagnosis increases the risk of Post Treatment Lyme Disease Syndrome (https://www.cureus.com/articles/24863-lyme-disease-with-erythema-migrans-and-seventh-nerve-palsy-in-an-african-american-man) and other long-term complications from Lyme disease.

Antibiotics are used to treat Lyme disease. In general, recovery will be quicker and more complete the sooner treatment begins. Many signs and symptoms of Lyme disease are often found in other conditions, so diagnosis can be difficult.

Covid-19 False Negatives

Researchers at Johns Hopkins have found that the chance of a false negative result -- when a virus is not detected in a person who actually is, or recently has been, infected -- is greater than 1 in 5 and, at times, far higher. The researchers caution that the predictive value of these tests may not always yield accurate results, and timing of the test seems to matter greatly in the accuracy. https://www.sciencedaily.com/releases/2020/05/200526173832.htm.

Lakeith requested a second Covid-19 test, which was also negative. He is currently taking a two-week course of oral Doxycycline.

Health disparities and Lyme

A recent study finds that African Americans who contract Lyme disease are 10% more likely than Caucasians to exhibit symptoms such as neurological or heart problems, and they are 30% more likely to suffer from arthritis as a result of the disease. Whites were nearly six times more likely than African Americans to have detected a bull’s-eye rash, according to the study, which may be due to darker skin color that hides the bull’s-eye rash. Because skin tone may hide this key indicator, African Americans may remain untreated longer and therefore suffer more complications from Lyme disease. This highlights the need for increased health care education on Lyme disease in African-American communities. https://minoritynurse.com/darker-skin-tones-slow-detection-of-lyme-disease/

Health disparities and Covid-19

Twenty-two percent of U.S. counties that are disproportionately black account for 52 percent of the nation’s COVID-19 cases and 58 percent of COVID-19 deaths (https://directorsblog.nih.gov/2020/05/14/covid-19-brings-health-disparities-research-to-the-forefront/)

In another study, 33% of hospitalized patients were black, compared to 18% in the community, and 8% were Hispanic, compared to 14% in the community. These data suggest an overrepresentation of blacks among hospitalized patients. Death rates among black/African American persons (92.3 deaths per 100,000 population) and Hispanic/Latino persons (74.3) that were substantially higher than that of white (45.2) or Asian (34.5) persons. (https://www.CDC.gov/coronavirus/2019-ncov/need-extra-precautions/racial-ethnic-minorities.html)

Racial disparities are a major issue with Covid-19. Evidence has emerged that doctors are less likely to refer African Americans for testing for covid-19 when they exhibit symptoms (https://www.washingtonpost.com/outlook/2020/05/18/most-medical-professionals-arent-racist-but-our-medical-system-is/). U.S. Senator Elizabeth Warren (D-MA) and Representative Ayanna Pressley (D-MA) have called for more thorough collection of racial data, faulting the government for “currently failing to collect and publicly report on the racial and ethnic demographic information of patients tested for and affected by Covid-19.” (https://www.nejm.org/doi/full/10.1056/NEJMp2012910)

Thanks for commenting and liking - I so appreciate it. I'm going to take some acetaminophen and go back to sleep. Ugh.

On 6/30/2020 at 9:23 PM, KatieMI said:

From the provider point of view:

1). Ddx question in this situation is principally nil and zero, because right now every patient is basically treated like COVID19 patient until proven otherwise.

It is not written if the patient came to urgent care, ER or primary care office, but with fever and aches and direct contact with people of increased risk he will be sent to testing place at once, and so the question about COVID19 will therefore be solved. It is not necessary to think about it or follow absurd protocols and checklists (by common sense anyone who visit any place with more than himself around cannot for all honesty say that he absolutely was not near anyone who had confirmed COVID unless everyone around him was tested negative and it is known). It is just necessary to recognize one simple fact of today: not confirmed "negative" = "positive" unless proven not by DOUBLE test PCR (antibodies are optional and possibly useless at the beginning of the process).

Once we answered the question about the COVID, we can proceed with further differential, which is a little wider than just Lime. And we are not forgetting that one can have COVID19 and Lime disease at the same time.

2) from answers: some of them illustrate very common mistake, particularly characteristic for nursing providers: ordering every test and the kitchen sink, at once, basing on some bits and pieces. It illustrates the classic American nursing way of thinking of "doing something for something".

Routine tests such as lipid profile, TSH or iron profile should NEVER be ordered in the middle of acute infectious process, trauma, severe acute exacerbation of chronic disease, in immediate postop period, etc. unless there is a compelling evidence of need to test such as well-based differential. A human being in acute period of infection is different from the same human being after recovery, in metabolic point of view. Doing otherwise leads to diagnostic mistakes and, eventually, harm. Assuming you got cholesterol of 275 on this patient. He is in acute stage of infection and already has muscle pains. He might have already, or develop soon, mild transaminitis. We may have to use quite a bit of Tylenol and other hepatotoxic meds on him. Do you really want add statin on top of this mess? If not, why spend $$ for inherently useless testing which can be safely performed later?

3). Again, line of thinking characteristic for nursing providers in particular: one big thing or no thing. Bull's eye =>> Lime disease, stop at that. Without even checking the total body surface. With the patient being 35 years old male, our differential must include syphilis (at secondary stage, it can produce skin rashes looking amazingly like bull's eyes) and several other common skin conditions like erythema multiforme, by a short list.

Overall, not a good example of clinical question. Sorry. But at least an attempt.

I thought it would make for an interesting and informative discussion. Thanks for reading and commenting.

I haven't taken care of any covid patients. I'm just here to learn something. Carry on. ?

Specializes in ICU, LTACH, Internal Medicine.
On 7/6/2020 at 5:59 PM, SafetyNurse1968 said:

Health disparities and Lyme

A recent study finds that African Americans who contract Lyme disease are 10% more likely than Caucasians to exhibit symptoms such as neurological or heart problems, and they are 30% more likely to suffer from arthritis as a result of the disease. Whites were nearly six times more likely than African Americans to have detected a bull’s-eye rash, according to the study, which may be due to darker skin color that hides the bull’s-eye rash. Because skin tone may hide this key indicator, African Americans may remain untreated longer and therefore suffer more complications from Lyme disease. This highlights the need for increased health care education on Lyme disease in African-American communities.

https://minoritynurse.com/darker-skin-tones-slow-detection-of-lyme-disease/

The fact that African Americans have higher incidence of arthritis as complication of Lyme is interesting and it is not a "disparity". It is not "rasist" to state the fact: African Americans have genetic markup of many conditions different from that of other ethnicities. Classic b-blockers therapy for CHF can be much less effective for them than it is for Caucasians, they have mutations of ACE receptors more common, they develop HTN-related kidney injury earlier and more severe because of it, their metabolism of vitamin D is different as skin synthesis of D2 is much less effective, etc., etc.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933289/ (one of many)

Darker skin tones conceal not only bull's eyes rash but many other rashes as well. This is why it is so important not to hold onto one symptom but develop "whole picture" systemic diagnostic vision and do not "fix" on symptomal/syndromal differentials. "Transaminitis" is a fact and a symptom, not a diagnosis.

I know it takes heck of time and decreases "productivity". But it is what have to be done. In every single case, no exclusions, whatever skin color and other variables might be.

Specializes in Oncology, Home Health, Patient Safety.
Specializes in wound care/rehabilitative care.

I am still leaning towards Lyme disease. When the answer is revealed it will be a good conclusion. I have been working with COVID-19 patients and we have had about 10% of our positive population, test or retest with a negative, and then within 48 hours retest positive. Has the patient been retested for COVID? Has he c/o any joint swelling which I had mentioned earlier especially in knee(s)?

Specializes in Oncology, Home Health, Patient Safety.
12 minutes ago, GracefullyGritty said:

I am still leaning towards Lyme disease. When the answer is revealed it will be a good conclusion. I have been working with COVID-19 patients and we have had about 10% of our positive population, test or retest with a negative, and then within 48 hours retest positive. Has the patient been retested for COVID? Has he c/o any joint swelling which I had mentioned earlier especially in knee(s)?

Please scroll up -I did reveal the answer and it is Lyme disease!

3 hours ago, SafetyNurse1968 said:

Just took second dose of doxy- fever is 101.9 this morning

Was your covid test negative? I've been following this thread like a soap opera.

Specializes in Med Surg, Tele, Geriatrics, home infusion.

Hope you are feeling better soon@SafetyNurse1968 ! Thanks for posting the case study, thought it was a good conversation.

Specializes in Oncology, Home Health, Patient Safety.
25 minutes ago, scribblz said:

Hope you are feeling better soon@SafetyNurse1968 ! Thanks for posting the case study, thought it was a good conversation.

Thank you! I really needed that- good convo is a good outcome.

42 minutes ago, NurseBlaq said:

Was your covid test negative? I've been following this thread like a soap opera.

IKR! Not back yet- will post as soon as it comes in! Thanks for your support.

Specializes in wound care/rehabilitative care.
5 hours ago, NurseBlaq said:

Was your covid test negative? I've been following this thread like a soap opera.

Me too ! Great read and kept me thinking