Contraindications for Tube Feeding and certain Medications

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Today Dilantin was held so a PEG tube could be stopped (Stop PEG for 1 hour, give Dilantin, restart PEG after 1 hour). The type of feed was "Nepro" (nutritional info, scroll down). How it was explained is that Dilantin clings to the "milk" in the tube feed and is excreted, thus not doing the body any good.

I looked up the ingredients for Nepro and it doensn't say anything about having milk. I also looked up Dilantin and that says it binds to "albumin."

Would you hold Dilantin if a patient was on tube feed (no matter the formula)?

What other drugs would you have to hold if a patient were on a tube feed?

Usage:

NEPRO is specifically designed and clinically shown to meet the needs and altered metabolism

of people on dialysis.

* In a study of Nepro as sole-source nutrition, people on dialysis had:

- Improved calcium-phosphorus product

- Decreased phosphate binder use

- Less constipation1

* For tube or oral feeding

* For supplemental or sole-source nutrition

Features:

# 1900 Cal (four 8-fl-oz cans) meets or exceeds 100% of the RDI for 18 key vitamins and minerals Low in vitamins A and D

# High in folic acid and vitamin B6

# Low in phosphorus and potassium

# Moderate protein content to replace protein lost during dialysis and to help prevent catabolism of lean body mass

# 3.7 g of FOS/8 fl oz (15.6 g/L). FOS are prebiotics that stimulate the growth of beneficial bacteria in the colon

# 3 flavors (8 fl oz)--Vanilla, Cherry Supreme, and Butter Pecan

# Low-residue

# Lactose- and gluten-free

# Kosher

Caloric Distribution

Per 8 fl oz

Per Liter

% Calories

Calories

475

2000

--

Protein, g

16.7

70

14.0

Fat, g

22.7

95.6

43.0

Carbohydrate, g*

52.8

222.7

43.0

Water, g†

166

699

--

*Includes 3.7 g/8 fl oz (15.6 g/L) of FOS.

†1 g water = 1 mL water = 1 cc water.

Analysis:

Hide details for Nutrient FactsNutrient Facts

8 fl oz

1000 mL

FAN (label number)7958-047642-01

Cal/mL2.002.00

Energy, Cal4752000

Protein, g16.770

% of total Calories

14.014.0

Fat, g22.795.6

% of total Calories

43.043.0

Cholesterol, mg

Carbohydrate, g52.8222.7

% of total Calories

43.043.0

Water, g*166699

Dietary Fiber, g3.715.6

L-carnitine, mg62261

Taurine, mg38160

m-Inositol, mg

* 1 g water = 1 mL water = 1 cc water.

Carbohydrate includes dietary fiber.

Dietary fiber: 3.7 g/8 fl oz (15.6 g/L) of FOS.

Hide details for VitaminsVitamins

8 fl oz

1000 mL

Vitamin A, IU10004215

Vitamin D, IU2085

Vitamin E, IU1248

Vitamin K, mcg2085

Vitamin C, mg25105

Folic Acid, mcg2501055

Thiamin (Vitamin B1), mg0.62.6

Riboflavin (Vitamin B2), mg0.682.9

Vitamin B6, mg2.18.9

Vitamin B12, mcg2.411

Niacin, mg834

Choline, mg150635

Biotin, mcg120510

Pantothenic Acid, mg417

Includes 750 IU/8 fl oz (3160 IU/L) of vitamin A activity from 0.57 mg/8 fl oz (2.4 mg/L) of beta-carotene.

Hide details for MineralsMinerals

8 fl oz

1000 mL

Sodium, mg (mEq)200 (8.7)845 (36.7)

Potassium, mg (mEq) 250 (6.4)1055 (27.1)

Chloride, mg (mEq) 240 (6.8)1010 (28.5)

Calcium, mg3251370

Phosphorus, mg165695

Magnesium, mg50215

Iodine, mcg38160

Manganese, mg1.35.3

Copper, mg0.52.1

Zinc, mg5.724

Iron, mg4.519

Selenium, mcg24105

Chromium, mcg

Molybdenum, mcg

Other Values

Density at 23°C, g/mL1.099

pH6.6

Osmolality, mosm/kg H2O665

Osmolarity, mosm/L446

Renal Solute Load, mosm/L491

Cal to meet 100% RDIs1900

mL to meet 100% RDIs947

Total Cal/g nitrogen179:1

Nonprotein Cal/g nitrogen154:1

Specializes in Gerontology.

We also schedule Dilantin doses around our PEG tube feedings. We have also been told that the milk or milk sustitute binds with the dilantin. I can't think of any other med we do this with.

Specializes in Neuro/Med-Surg/Oncology.

We also would have to hold our Dilantin re: tube feeding. One way we worked with it was to get the docs or PA's to order the Dilantin 300mg qhs instead of 100 mg tid. That way the pt's feeding was only held for 2-3 hours total, instead of 3x a day. We would also try to get orders for Prosource or another supplement to boost the calories and nutrition that they were taking in.

i've never held fdgs w/dilantin.

our pharmacy told us that as long as we diluted it w/sterile water, dextrose 5% or 0.9% nacl, then flushed with minimum 20cc after administration, then nothing would stick to the tubing.

dilantin can interact w/milk products but absorption is so variable that many md's do not consider milk a huge contraindication.

there are too many other interferences w/dilantin, tube fdgs not being one of them.

i know nurses have always held fdgs for an hr.

but when i went to investigate why, the above, is what our pharmacy told us.

and further research came up with similiar findings.

leslie

Specializes in pedi, pedi psych,dd, school ,home health.

i have also mixed the dilantin with H20, and given with flushes both before and after. if the individual is not on a continuous feed it does help to schedule it when the feed is off. i have also found that crushing the chewables and diluting works better than the suspension, as it does not evenly distribute even when shaken..we found that dilantin levels drawn were quite inconsistent .

Always flushed prior to administration of Dilantin and after administration of drug with plain tap water per pharmacy and doctor's orders. We are a little more generous than 20 cc. In fact, may give a total of 100cc if patient has no respiratory problems, abdomen is nondistended, bowel sounds are positive x 4 quads, and tube placement was verified x 2 nurses. Most patients who get tube feedings do not get recommended H2O intake, so urine is concentrated, giving a little extra water when able just promotes better urine output.

Always flushed prior to administration of Dilantin and after administration of drug with plain tap water per pharmacy and doctor's orders. We are a little more generous than 20 cc. In fact, may give a total of 100cc if patient has no respiratory problems, abdomen is nondistended, bowel sounds are positive x 4 quads, and tube placement was verified x 2 nurses. Most patients who get tube feedings do not get recommended H2O intake, so urine is concentrated, giving a little extra water when able just promotes better urine output.

absolutely!

i was just repeating what pharmacy told me- a minimum of 20cc.

what many don't understand that despite continuous feeds, many of these pts do not get enough free water so in the absence of any contraindications, and w/the recommendations of the rd and md, we've given 500cc h2o tid-qid.

leslie

Our docs routinely switch the Dilantin with Trileptal. The absorption rate is very unpredictable when giving dilantin and continuous tube feedings.

Specializes in Geriatric and now peds!!!!.

We have 2 residents on tube feeds that take Depakote, our orders are to stop the tube feed for 1 hour before and after giving the med, flush well while giving the med, and then restart feeding after 1 hour.

Wendy

LPN

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