This is happening to me too! I think I'm developing an allergy on my hands and wrists to the blue contact gowns we use with isolation patients. At work it's fine because the Purell seems to soothe the itch, but at home that night and the next day it's pure torture! I actually thought it was ringworm at first (ew) but my dermatologist said it's probably contact dermatitis. Hydrocortisone doesn't even touch it, so I've been using fluocininide 0.05%, which takes a while to kick in but does the trick eventually.