Is anyone out there applying to TWU for the Fall of 2010? I got this idea from a previous thread and thought I should get one started for this semester, so that we can help each other and communicate with each other?
I have taken the Hesi-A2 and got a 74.8 on it so they didn't even look at my application. I live on campus so any help or information I can give just let me know. I'm excited and feel good about this deadline.
Can someone please explain to me why epithelial proliferation in AGN and RPGN causes glomerular destruction? I understand the A&P of the glomerulus, but I don't see how more epithelium/podocytes causes GBM damage.
Is it because with epithelial proliferation you also have more anti-GBM immune complexes?
can someone please explain to me why epithelial proliferation in agn and rpgn causes glomerular destruction? i understand the a&p of the glomerulus, but i don't see how more epithelium/podocytes causes gbm damage.
is it because with epithelial proliferation you also have more anti-gbm immune complexes?
thanks
hey ryan,
good question! i found this on wikipedia and backed it up with our text book (page 676, top of 2nd column):
histopathology: the majority of glomeruli present "crescents". formation of crescents is initiated by passage of fibrin into the bowman space as a result of increased permeability of glomerular basement membrane. fibrin stimulates the proliferation of parietal cells of bowman capsule, and an influx of monocytes. rapid growing and fibrosis of crescents compresses the capillary loops and decreases the bowman space which leads to renal failure within weeks or months.
it seems that in rpgn, the lesions that are formed grow in size (because of epithelial proliferation and fibrin deposition). the increased growth blocks the capillary loops and leads to renal failure.
Berger disease (a type of GN) has respiratory and gastrointestinal viral infection triggers that release IgA. Complement is activated and inflammatory cells are released causing glomerular damage. (page 676 bottom left column)
umm...OMG!!! So, I knew that we were accepted into the program. Patho was to get my feet wet. I am excited but after reading that 23 page syllabus, I am exhausted! I believe I am experiencing the clinical manifestations of anxiety:uhoh3:
FYI- you WILL need your scrubs for NRS 3614. Not being in scrubs affects your grade drastically! Not sure if this means they are needed on the first day but as thorough as the syllabus is...it seems like not needing them would have been stated.
umm...OMG!!! So, I knew that we were accepted into the program. Patho was to get my feet wet. I am excited but after reading that 23 page syllabus, I am exhausted! I believe I am experiencing the clinical manifestations of anxiety:uhoh3:
FYI- you WILL need your scrubs for NRS 3614. Not being in scrubs affects your grade drastically! Not sure if this means they are needed on the first day but as thorough as the syllabus is...it seems like not needing them would have been stated.
After reading more...scrubs are required the first day!
RyanT
148 Posts
Can someone please explain to me why epithelial proliferation in AGN and RPGN causes glomerular destruction? I understand the A&P of the glomerulus, but I don't see how more epithelium/podocytes causes GBM damage.
Is it because with epithelial proliferation you also have more anti-GBM immune complexes?
Thanks