Published Aug 7, 2006
john 1947
10 Posts
Propofol should not be used for long term sedation. Few people know of this deadly drug reaction
Many Europen countries know the truth about this very unpredicable drug.It's time to open honest discusion about it's shortcommings here.
RoxanRN
388 Posts
I'm be interested to see your literature.
traumaRUs, MSN, APRN
88 Articles; 21,268 Posts
Can you provide us with a citation? Thanks.
NRSKarenRN, BSN, RN
10 Articles; 18,926 Posts
the pathophysiology of propofol infusion syndrome: a ...
propofol: contraindicated for sedation of pediatric intensive care ...
toward a prediction of sudden death in propofol-related infusion ...
pedsccm: eb journal club review
the fda warning against prolonged sedation with propofol in children..
propofol: danger of prolonged and high infusion rates in icu
I am looking for nurses who have had first hand experince dealing with patients with the propofol infusion syndrome.
Sharing of information for educational purposes is purpose behind website. If looking for nurses for testimony in lawsuit, please look elsewhere.
Im not looking for testimony in any lawsuit. My only desire is to make aware this problem. Money has no value to me, Im only looking for truth and to avoid this happening to another.There has been enough discusion how many more lives will it take before a black box for adults as well as children on this drug is mandatory.
gwenith, BSN, RN
3,755 Posts
I have to say that I was not as aware of this but then Propofol is ONLY used for 24 - 48 hours here. It is never used for long term sedation and we tend to use lesser amounts. Cost of the drug is one reason why we have limited use but the other is we have a higher patient nurse ratio in Australia and that leads to lower sedation levels.
I've never heard of it until now. Since we've gotten out new intensivist, we don't use it as often. To my knowledge, we haven't had problems that have been/can be attributated to PRIS (not saying it hasn't happened, just not aware of any).
I am glad I am not alone - oh! Well we live and learn - obviously this has been a bigger problem in paeds than in adults and we are only now starting to see a connection. Some of the problem is that MODS is so common in adults that there may have been some deaths that have been attributed to other factors.
JenSICU_CCRN
48 Posts
we only use it short term as well since there is in increased rate of infection while using propofol due to it being lipid based. also, we don't use high doses since it affects bp adversely sometimes....we are extremely careful with it in our unit.
jenny
Has anyone hit the phenomenon of increased tolerance to propofol in adults - especially those who have a background history of drug abuse and most particularly marijuanna intake??
I think I am seeing a correlate here.