I've worked at two of the two of the hospitals in downtown St. Paul, after working in Baltimore, Maryland. Currently studying for my BSN at a very nearby college in St. Paul. In saying so, I've felt incredibly safe in Lowertown. My initial intention was to acclimate to Minnesota's urban life for one year, then move to the comfy suburbs. To-date, I'm quite content being a 10-minute bike ride-- or 15-minute walk-- away from work. I don't actually know much about the Minneapolis area; Hopefully, someone else can advise you regarding those areas.
(The following notes the state of my neighborhood before COVID and present-day civil unrest.) Lowertown has lots of options for luxe living, whether that be apartment or condo style. You'd be close to bars and nightlife (albeit less than downtown Minneapolis). There's a grocery store, Lunds & Byerlys, and local farmer's market available within walking distance. Lots of bus routes pass through as well, if you choose not to drive. My favorite feature of the neighborhood has to be the cycling routes along the Mississippi River, connecting me to various parts of the Twin Cities.