I am far from a social creature, and I can completely understand where you're coming from. I have a very dark, dry, and crass sense of humor, so most people simply don't "gel" with me, and that's fine. While things like group projects and clinical presentations are a group effort, you are there for YOUR degree, like Mergirlc mentioned. My classmates are often going to grab a few drinks after exams or chatting before class, while I go home after exams and am usually trying to shove some semblance of dinner in my face before class starts. I don't concern myself with making friends, mainly because the likelihood of you really relying on your network of nursing school friends after graduation is slim (in my opinion- I'm sure there are plenty of folks who made lifelong friends in nursing school).
That being said, I think your being a true "outsider" in the sense that you're coming from out of the area makes things more difficult. Do you have a support system beyond school? Someone/some people you can just vent to even if they aren't totally understanding the ins and outs of the program? I vent to my supervisor at work all the time, just to blow steam off (you will discover there is a lot about nursing school that seems to be stupid busy work with no real payoff).