IV Phenergan and Toradol "Push"

Specialties Emergency

Published

Just thought I would bring a recent experience up for discussion:

29 May I end up in ER w/24 hours of extreme chills (long sleeve T-shirt, PJs, 2 blankets, quilt and down sleeping bag), intermittent, transient bone and joint pain, nausea and vomiting. I was given an IV set near the base of the thumb for fluids and then an IV "push" of phenergan and toradol at the site of the IV set rather than up the line where it would have been somewhat diluted. As a 30 year Crohn's disease patient I have had PLENTY of IV and IM phenergan and demerol w/o any discomfort or problems. But this one BURNED and HURT! The nurse continued the "push" and explained that it was the phenergan. I didn't really believe this given my previous experiences and assumed it was really the toradol as that was my first experience with it. The pain and burning only lasted a few minutes after the "push".

I had no swelling of the hand or arm, no pain, no redness for several days. Long enough that I never even thought of the IV push when I began with a bruised type feeling on the inside of the arm just above the wrist and the outside of the arm 1/2 below the elbow. Several days after that I did notice a hard stretch of vein about 3/4" long 1/2 way below the elbow on the outside of the arm. Later a "bump" at the wrist, still later another 3/4" hard stretch of vein just above and a little to the outside of the bump. And then a 1/2" hard spot in the vein below the base of the thumb at the wrist. It finally occured to me that this was probably the result of the IV push but since there was no redness, no swelling, no tenderness unless I kept poking the areas I didn't bother seeing a doctor about it. (Heaven knows I see him enough as it is, bless his heart!).

21 July the "bump" at the wrist turned red and was tender. Hot compresses did nothing for it that evening nor the next morning. My family doctor isn't in the office on Fridays and I figured the ER IV push was the cause so I went to ER. I was told it was "just" superficial thrombophlebits that could take as much as 6 months to resolve and was about to be released (which was ok with me as long as the doctors weren't concerned). But the "lead" ER doctor came in, first time I had seen her, and she said she would feel more comfortable ordering a venous ultrasound before I was released as she had had 2 STs go "sour" on her in the previous 3 months. I didn't have a problem with that so of course I agreed. What the heck, she was the doctor.

Ha! Turns out I had a deep vein thrombosis in the axillary vein in that upper arm! You could have floored me!! I ended up being admitted and given IV heparin drip and oral coumadin. Upon release 3 days later I had to agree to daily blood draws which was a cheap price to pay to be released from the hospital since I didn't feel sick and didnt hurt.

I've since been reading up on STs and DVT and realize my part in letting things go so far. However, I've found quite a bit of controversey on IV phenergan (and also demerol). The Infusion Nurses Society Standard # 43 specifically states phenergan should NOT be given IV due to its PH and potential for harm.

Frankly, given my experience thru the years and the blessing that IV and IM phenergan (and demerol) has been I would hate to see its use be discontinued. However, this was the first and only time phenergan was ever administered IV that close to the IV set instead of up the line where it gets diluted w/the IV fluids.

I'd be interested in your thoughts and experiences on this event and the use and method of administering IV phenergan. Mind you, my mother worked at this hospital all the while I was growing up, other than Mayo Clinic it is the only hospital I have ever gone to (altho we have another in town) and I've been volunteering here for several years in Endoscopy or Messenger Service. I'm not looking to cause any trouble and I know my ER nurse from previous encounters in the cafeteria and elsewhere at the hospital and he is a fine and conscientious nurse. He was marvelous when my brother in law was brought in with an AAA.

Didn't know that about liver patients and LR, don't work with them much. Thanks for the tidbit.

Actually phenergan is the only thing that works to control my nausea. My concern was the way it was delivered. They fried my vein by administering it slowly yes but undiluted. They were in a hurry and more focused on getting me checked off on their to do list. I'm concerned that this is the product of the nurse shortage and instead of the nurse following her conscience and doing what's right for the patient her priority was to get a job done fast to please her superiors. Quantity instead of quality. I sure hope this is not the new breed of nurses who see nursing as a steady job rather than a calling. When the hospital I worked at did away with orderlies who came to get patients up out of bed and did transfers they lost more professional staff to back injuries. But one thing I must say is that we nurses stuck together and fought to provide better care for our patients. I believe it is important to do what you know is right even if it means defying an order - which I have done. I remember an incident in ICU where I was newly employed and the Doctor ordered me to hang a bag of Lactated Ringers on an end stage cirrhosis of the liver patient. I asked him if he was kidding. He said no. I said I can't do that, it will send that patient into a hepatic coma. Fortunately this Doctor was humble enough to ask why and after respectively explaining how the liver in these patients cannot breakdown the lactic acid he asked which IV fluid I thought best to use. Again amazed, but at least the patient survived. So I encourage my fellow nurses to be the leaders in maintaining dignity to our profession and hold fast to what you know is the right thing to do.

Yoda

Specializes in Gerontological, cardiac, med-surg, peds.
Didn't know that about liver patients and LR, don't work with them much. Thanks for the tidbit.

Lactate is oxidized by the liver to bicarbonate. Lactic acidosis may occur in association with an underlying disease, such as diabetes mellitus, severe iron-deficiency anemia, liver diseases, alcoholic ketoacidosis, pancreatitis, malignancy (eg, leukemias, lymphomas, lung cancer), alkalosis, infections (malaria, cholera), renal failure, pheochromocytoma, thiamine deficiency, short gut syndrome and other carbohydrate malabsorption syndromes. Lactated ringers should also be avoided in these circumstances.

http://www.emedicine.com/emerg/topic291.htm

Concentration of Electrolytes in LR (mEq/liter): Sodium - 130, Potassium - 4,

Calcium - 3, Chloride - 112, Lactate - 28

Lactate administration is contraindicated in severe metabolic acidosis or alkalosis, and in severe liver disease or anoxic states which affect lactate metabolism.... Solutions containing lactate should be used with great care in patients with metabolic or respiratory alkalosis, and in those conditions in which there is an increased level or an impaired utilization of lactate, such as severe hepatic insufficiency... Excess administration may result in metabolic alkalosis.

http://www.fda.gov/medwatch/SAFETY/2004/sep_PI/Dextrose%20Lactated%20Ringers_PI.pdf

LR Contraindications: Severe lactic acidosis and severe hyperglycemia:

http://www.inshealth.org/Formulary/formulary-L.htm

Lactated Ringers solution should not be administered to patients exhibiting clinical signs of lactic acidosis.

http://www.perfline.com/textbook/local/conduct_vinas.html

Phenergen should always be given IM. Due to high PH it gives the burning sensation when given IV.

Angie O'Plasty, RN said:

Our policy is to dilute Phenergan as the others mentioned, but where I have a choice I'll start asking for Anzemet instead. But first I need to ask if you Crohn's patients ever tried that? Is it effective for you? I've never had any complaints about it and it seems way less sedating than Phenergan.

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Unfortunately, Crohn's is a VERY individualized disease, even when it comes to what foods we can or can't eat. I've never been given anything else for nausea except phenergan so I have no idea what else, if anything, works for me. Its not something I ask for, I just get what they give me. I take that back. I did ask my gastro once for phenergan tabs, when I learned that they even existed, for use during a scope prep since I get so violently nauseous with vomiting with the Lytely products. You're right tho. One phenergan tab put me to fighting sleep for a good 20 hours! Never had it that bad with the phenergan IV or IM. It worked for the nausea tho!!! Thankfully now I am allowed to use the PhosphoSoda or Magnesium Citrate prep instead and an extra day of clear liquid diet so I don't have to "do" the Dulcolax tabs as well which give me painful cramping. Many meds are effective for me at 1/2 dose and cause bad side effects at full dose.

My son is a crohnie also! Welcome to our family. My experience as a nurse leads me to believe that maybe if they would have diluted the push before giving it, the burn wouldnt have been so bad. Phenergan is a very damaging medication and should be given slow (helps). Sorry to hear about your experience, hopefully we all learned something from it.

I'm sorry your son also has Crohn's. I hope it is mild and he is doing well with it! I was pleased, the Director of Pharmacy came to talk to me after I provided him with printouts of many of the comments here and he has assurred me that they are reviewing both the hospital and ER protocols re: phenergan and toradol administration so that hopefully similar incidences can be averted in the future. I've had such good luck w/IV and IM phenergan in the past that until and unless we find something else as effective for me I would hate to see it eliminated from our hospital's formulary despite this recent experience.

From mid 1975 until my resection in early 1978 I was nauseated 24 hours a day, 7 days a week, the entire 2 1/2 years in addition to the pain and bloating. The only relief I got those 2 1/2 years were occasional trips to ER and IV phenergan and demerol, usually just about the time my menstrual period was due. In fact, it was the ER physician who noticed the cycle and suggested BC pills to stop my periods! Before we could try that I ended up fully obstructing, fortunately I'd flown to Mayo Clinic and so I had my emergency resection there. Good luck and God bless to your son!!!

Specializes in Utilization Management.

Thanks for your response, Crohnie. :) I'll be sure to keep those things in mind with my Crohn's patients.

By the way, I do so want to thank each and everyone of you for your replies to this thread. I so very much appreciate them. And I appreciate that I was allowed to post my experience and questions here. Thank you!

Yes, Toradol burns, I've also been on the receiving end and had pt's tell me it burns. I also dilute the Toradol with NSS before giving it. Maybe the combination of two very irritating drugs made you even more predisposed to DVT. We don't use Phenergan very much but when it's ordered IV it is diluted.

We use a lot of Reglan and Zofran. I've found Reglan can cause people to get very anxious sometimes. Anyone else had this happen?

I always dilute Phenergan very well, give it very slowly through the highest port and flush well behind it. It is very irritating.

I hate heplocks in general.

And yes, I have seen the Reglan reaction several times, anxiety, chest pain, sweating....I hate when that happens.

Specializes in ER, PACU, OR.
Just thought I would bring a recent experience up for discussion:

never had anybody c/o Toradol, or phenergan burning when infused. The more comon complaint with phenergan, is a metalic taste (which conicidentaly you can get with Toradol also).

My guess is, you had a clot already, maybe a phlebitis which could have been the cause of the fever and chills? Pushing up into that vein with a clot proximal, probably was the cause of the buring.

Good Luck!

Just thought I would bring a recent experience up for discussion:

never had anybody c/o Toradol, or phenergan burning when infused. The more comon complaint with phenergan, is a metalic taste (which conicidentaly you can get with Toradol also).

My guess is, you had a clot already, maybe a phlebitis which could have been the cause of the fever and chills? Pushing up into that vein with a clot proximal, probably was the cause of the buring.

Good Luck!

I've often thought the same thing . . . IV sites go bad and maybe it was just a coincidence that it hurt with the phenergan.

I give it all the time in the ER through the IV and no complaints . .. I also just gave 30 mg of Toradol IVP . . no complaints.

steph

I always dilute with 10cc ns and push very slowly.

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