For opiate ODs, you give Narcan-and man, can they become nasty & combative when they wake up and find out you ruined their high! Then it's mostly supportive tx with IVs, monitors, etc,-and more Narcan prn, because Narcan doesn't last as long as the opiate. Once they're stable, they can have a safe medical detox, using methadone. For ETOH, supportive tx again, depending on s/s. IVs, monitors, seizure precations (tx seizures with IV Valium), etc, until the patient wakes up and is stabilized for medical detox. Then we use po/im Librium every 2 hrs prn until patient is detoxed.
Pills-just usually supportive, although activated charcoal thru an NGT and/or gastic lavage is used if the OD is recent enough that the pills may remain in the GI tract.
Coke, m/j-usually just supportive tx.
I'm not usually in on the acute phase in the ER or the ICU. I get 'em when they are stabilized!
Hope this helps!