Case Study: Fever

The following is a case involving a patient with fever. As the case evolves, I will present assessment findings, lab results, and diagnostic results in the hope of eliciting responses on how we would approach the care of this patient.

Updated:  

The following is a case involving a young male who presents with fever associated with respiratory symptoms. This is based on a real case. The events leading to his hospitalization and his course in the hospital will be portrayed in an attempt to stimulate discussion on ways to approach his care not only from a nursing standpoint but also to understand the complexity of his care from the perspective of other disciplines who will be involved in his care particularly his medical management.

Background History

Rolando is a 19-year old college student who is the son of first-generation immigrants from the Philippines. His parents are divorced and he lives with his mother in a coastal town close to where he attends college. He decided to skip the fall semester and live with his father in California's Central Valley region to help him run a small business.

He presented to his family physician with complaints of productive cough for about 7 days and feeling warm and flushed. He said his phlegm looked white in color and not excessive. He appeared healthy and has no medical history other than having had his appendix removed at age 14. The physician prescribed him Azithromycin and cautioned him to seek further care if his symptoms do not improve. He recalls having some tests done at the clinic but was not sure what they were.

Three days later, Rolando was feeling worse. He feels he is warmer and may have a high fever, is having chest discomfort with coughing while not expectorating any phlegm, and is experiencing joint pains and muscle aches. He has no appetite and is feeling weaker. His father was concerned and brought him to the nearest ED at a community hospital setting.

Social History

His social history is notable for being a college student with an undecided major. He admits to drinking alcohol occasionally but denies binge drinking, he does not smoke, he admits to having smoked marijuana in the past but not recently. He has a girlfriend in college and is sexually active.

You are Rolando's first contact in the ED as the triage nurse.

After gathering the above, you obtained the following data

  • Subjective complaints: "feeling warm, headache, little short of breath".
  • Vital Signs: Temperature 39 C, HR 112, RR 32, BP 110/65, O2Sat 88% on room air
  • Neuro: AOx3, moving all extremities, pupils equal and reactive.
  • CV: EKG showed Sinus Tachycardia with no ST changes, no murmurs were heard on auscultation, no edema in extremities.
  • Pulm: Harsh breath sounds bilaterally but no accessory muscle use. He does breathe fast as you noted in his respiratory rate.
  • Skin: Warm and flushed, you notice what looks like a red rash in his bilateral shins.
  • Remainder of the system exam is WNL.

How would you triage Rolando and what tests would you expect to be done in his case?

What would you tell the next ED nurse who will take care of Rolando once you determined the appropriate ED treatment area he should be treated at?

What concerns do you have about what is likely the reason for his symptoms?

Specializes in MICU, SICU, CICU.

87 is a completely normal blood glucose. Not at all a "tad on the low side". If he is fasting so much the better his fasting BG then would be completely normal

Agreed, his glucose is fine. Especially when you consider that he probably has been fasting (not feeling well, working hard to breathe). Also his PCO2 is not high (maybe you were looking at his PO2 instead). 36 is actually on the lower range of normal, which makes sense because he is tachypneic. So we know that this isn't a ventilation problem, it's an oxygenation problem. Why is he hypoxic on 100% FiO2? I'm anticipating that he'll need to be intubated. Maybe we could try turning up his flow on the high flow for a little PEEP, but I think we're running out of options. I guess we could try NIPPV as long as he can manage his secretions. Overall I think he'll probably need a bronchoscopy, so intubation is looking like the best idea to me.

As for a diagnosis? For some reason the eosinophilia caught my eye, which is making me think fungal/parasitic, maybe even toxin related. What about carbon monoxide poisoning?? With the headache, flu-like symptoms and hypoxia?

What about lymphoma? Check out the what looks like small masses on both sides of the trach. Also, elevated lactate is a classic sign of lymphoma.

Final answer = Non Hodgkin's Lymphoma

Specializes in Med-Surg.

My first thoughts were TB, or influenza? Was a LP done?

Completely agree that he seems to be starting to CTD. BiPap and intubation seem likely. Also, since pulmonary embolism seems possible, prepare for IV heparin/sc lovenox? Not sure if still acceptable treatment for this, but it was last time I was working in an acute setting lol.

Specializes in MICU, SICU, CICU.

I think Rolando is on the quick path to intubation. Bipap doesn't seem that it will likely be beneficial given his hypoxemia and most likely has an underlying process that will resolve over days rather than hours. I wonder about contacts with animals. I really wonder about viral etiology something like hantavirus that is endemic to the area and presents with fever and respiratory failure.

Specializes in Oncology.

Never seen it on real life and just throwing it it there, but legionairres?

Specializes in Oncology.

I'm (only) a student but I too was thinking lymphoma or fungal infection. My first thought before seeing the CXR was HIV or another STD.

Eh, 80 is the low side of normal for glucose, so it caught my eye. And I know absolutely little about ABG's, but not in my normal practice. And yes, Sara, PO2--

He is not oxgenating well--

Legionairres is a good thought too. Lymphoma, fungal infection also good thoughts...

Was a CT of the chest done, and what did that show?

Specializes in Oncology.

This is inspiring me to share an interesting case I saw a few years ago now. Loving these. Need to remember the details of mine and do some research.

Specializes in ACNP-BC, Adult Critical Care, Cardiology.
jadelpn said:

PCO2 a little high (?) so no increase in the oxygen to decrease drive....

Also, not entirely thrilled with the glucose #. Not awful, but it is glaring out at me--

OP, quick guide on acidosis/alkaline.....is this pertainant to this case?

ABG's give a lot of information. Acid-base balance is one. It also lets us know how adequate oxygenation and ventilation are. In the initial ABG, the pH is 7.40 which is in the middle (range is 7.35-7.45), bicarbonate is not really low so no metabolic component. PCO2 tells us about ventilation which 37 is within normal. Many posters already alluded to the profound hypoxemia (low PO2).

Specializes in ACNP-BC, Adult Critical Care, Cardiology.

Great responses!

A rapid HIV screen was done given the concern for an immunocompromised state that might have brought on an overwhelming and diffuse infectious pulmonary process based on the CXR and the profound hypoxemia. The result was negative. RPR was also sent and was negative.

And yes, the ED team decided to intubate because of the profound hypoxemia and increased work of breathing noted. The CXR findings were more consistent with an infectious process rather than pulmonary edema. But before I proceed, a note about intubation vs trial of BiPAP:

Many physicians are using BiPAP as a bridge in patients who presents with acute respiratory difficulties to avoid intubation. This website does a good job explaining this modality and how to make decisions when one is stuck between intubating and seeing if BiPAP could improve the clinical picture: BiPAP vs intubation

Back to the case:

The ED physicians spoke to Rolando and his father about the need to intubate. Both were agreeable with the plan and wanted to do everything possible to help Rolando.

A rapid sequence intubation followed. You will be assisting with this. A question, for the ED nurses in community hospital settings, what are your roles in this procedure? do you administer induction agents (Opioid/Hypnotic and Paralytics)? Just thought I'd ask.

Rolando's Vital Signs before intubation were: Temp 38.5, HR 120, RR 37, BP 140/80, O2sat 92% on HFNC at 40 LPM.

The physician decided to use Propofol and Succinylcholine for induction. Continuous monitoring equipment was made available and was checked that they were working. These included: continuous telemetry, continuous pulse oximetry, non-invasive BP cuff cycling at q 1 minute, and end-tidal CO2 monitor. You have placed two Gauge 18 peripheral IV's on each of Rolando's upper extremities and you have a bag of 0.9 NaCl 1L attached to one of his IV sites.

The physician placed a well-fitting ambu-bag mask with a tight seal over Rolando's face. He began to deliver breaths to pre-oxygenate, a technique performed prior to intubation the purpose of which is to flood the lung's functional residual capacity with increased oxygen levels so that enough reserve is available while the patient is paralyzed and not breathing during insertion if the oral endotracheal tube.

After administering Propofol and Succinylcholine IV, patient was intubated successfully. Condensation was noted inside the breathing tube, end-tidal CO2 was 30, and bilateral breath sounds were heard over the patient's lungs. The endotracheal tube was secured by the Respiratory Therapist. Subsequent CXR revealed the Endotracheal Tube's tip to be 3 cm above the carina.

The physician wanted to start with Assist Control, Volume Cycled Mechanical Ventilation. Rolando is 5 feet 8 inches tall. His orders were: Set Rate 20/min, Tidal Volume 500, FiO2 100%, PEEP 5. Propofol IV infusion was started. Immediately after intubation his vital signs changed to:

Temp: 38.3, HR 100, RR 20, BP 85/40, O2 sat 96% on the above ventilator settings.

What could possibly explain these changes and what would you anticipate next?

I'm a student so bear with me.

I'm thinking he has lead or pesticide poisoning that is causing hemolytic anemia. Perhaps he inhaled pesticides--Central Valley is known for agriculture. Also rash at shin level suggests leaning up against bushes; perhaps to harvest something or he was walking and spraying pesticides at knee level. WBCs are elevated to clear the particles and that could be the infiltrates seen on the cxr. I'm not sure if giving more oxygen or preparing for intubation is wise; he has good ventilation but poor carrying capacity. I'd anticipate orders for packed RBC and chelating therapy.

What business is his father in? Where do they live/farms nearby that do crop dusting?what home remedies have they tried?