When I had a bunch of courses with lots of notes, it was one binder per course, dividers for each week.
Then when I had not so many notes, it was one big binder, with dividers for courses.
Then this past semester when I had little to no notes at all, it was one half size notebook for EVERYTHING, including personal life. Just seperated everything with date. And let me tell you, it has been awesome. Everything I have written down in the past 4 months is in that book. Phone numbers, addresses, class notes, words to look up, preclinical notes, calender events, etc. I'm definitely going to stay with this system for a while.