Rolling backpack all the way!!! Once you get your nursing textbooks you will be glad!!! If money is tight you can get one for 20-30 dollars on amazon. Name brand Olympia. My nursing classmates and I all bought one with different designs!!!
Rolling, even if you don't have a lot of walking the books are still heavy. I have a pretty color and people definitely know its me coming down the hallway haha. Though it sometimes does get top heavy. I'm going to start carrying two plastic crates in my car so my bag isn't so heavy.
Just make sure it is made from durable material. My 1st semester my backpack tore halfway through. My one textbook is 10lbs and we need it every day. Another strategy is to make friends with the person beside you and share the load. We sit at tables of two and the first semester I brought one of the heavy books and my table partner brought the other one, it worked well.
I used the Vera tote by Vera Bradley for my pre reqs, but just recently got the get carried away tote for nursing school...which I start in 7 days. The bag is huge and can hold my huge books, binder and laptop. The straps are also padded for extra comfort.