Absolutely, but as stated, the doc can decline to do the procedure. I get yearly colonoscopies and after one absolutely horrible experience with Versed (Midazolam), I would never consent to that drug again. The long-term memory loss and the depression has to be experienced to be believed. About 90% of patients have a decent experience with Versed; but 10% do not. Most patients leave the endoscopy suite in a semi-daze and appear to be content; in about 10% the nightmares etc. start later. I used to think that the horror stories about Versed (askapatient.com or versedbusters) were a little exaggerated, but I have never heard of a drug that was so hated to have it's own website. My degree is in clinical pharmacology; I believe that patients who are properly consented beforehand by a nurse (ie: this drug is being given so you will forget the procedure, not: this drug is to make you comfy) will, for the most part, do o.k. with Versed. I was not properly consented, and even though I know a lot about benzodiazepines and GABA-A receptor theory, the creepy amnesia from Versed haunted me for a long time before I figured out what was wrong. Even now, facing painful elbow and wrist surgery on both arms, I'm sure that I will consent only to a Bier Block without any sedation whatsoever. Sure, discuss your options with the GI doc beforehand; any reasonable doc will let you skip Versed, if you need something for pain consider Fentanyl only. But I hate to say it, most GI docs like an amnesic patient and only see the patient immediately after the procedure and the problems start later. My last 2 colonoscopies were with nothing; each time I was ready for them to try to talk me into conscious sedation..when I mentioned problems with Versed, the doc agreed immediately and she told me that they had a lot of patients complain about it and that she would not consent to receiving it herself. I had my latest colonoscopy at the hospital where I work an I made sure that everyone knew my low opinion of Versed and the doc assured me that I would not get it. I was surprized when they had a problem with me declining the IV (I wanted to make sure that there were no screw-ups); the nurse who wanted to start the IV was a CRNA; my doc had called her in so that I could get Propofol instead of Versed. When I declined Propofol, the CRNA told me that there was no extra charge for her services (as a courtesy since my first exam was a disaster and I was given Versed even though it was a listed allergy. She was somewhat disappointed that I no longer trust sedation of any kind; all of this could have been avoided if a nurse was available to do informed consent for the first procedure-never let economics or scheduling remove your professional nursing skills from the process-you are essential to patient safety. Interestingly enough, the CRNA told me that she would also decline Versed and that she almost never uses it. Unfortunately, I doubt that I will ever consent to any type of sedation, no matter ho painful the procedure. And I know better; a bad experience with Versed can do that to you, even if you have a Ph.D. Just make sure that you get real informed consent before and type of mind-altering drugs are administered.