The idea of hiring a traveler is to have someone who is able to walk in to the facility, be taught any hospital specific policies, and any special computer systems, and take an assignment. They will expect you to know how to handle most normal situations. Some facilities will not treat you very well, others will be really happy to have help.
I've been a traveler, and worked with travelers. The way you are treated has a lot to do with how you handle your assignments, carry your work load etc. It can be difficult, and also at times, lonely...as you blow into town, and then right out of town. The more assignments I did, the "better" I got at functioning in the role of a traveller. I had come from a Level one trauma center that was very heavy on protocol, and went to so many institutions where policies were much more lax than I was used to...so I had a lot of surprises. Patients were all the same, and staff personalities were essentially the same, but being sure to do something the way your institution wants you to...is sometimes a challenge!
I recommend you sign on with a local agency and work some shifts at a few different locations, so you can get a taste of what it is like before you quit your job, or travel across country. I'm glad I did the travel nursing thing, but I also admit, I am now much happier to travel on Vacation!