Rifampin clotting PICC lines

[aimeern33]

Is anyone else having a problem with rifampin clotting off their picc lines? We had a picc that had only been in for a day clot off during the rifampin infusion. One of the NNP's that I work with said she has seen this in the past and even seen it happen with a Broviac. Anybody else with similiar experience?

[MegNeoNurse]

i haven't seen a kid in our nicu on rifampin - was it for mrsa?

(sorry, i can't answer your question-)

[aimeern33]

yes, the rifampin is for a mrsa positive blood culture and the baby is going to be on it for 30 days. The NNP even tried running a heparin drip with the med to prevent the problem and of course that did not work as the problem is not a blood clot but i believe a problem with particulate from the med. It actually clots off mid infusion.

[BittyBabyGrower, MSN, RN]

We have used rifampin and we haven't had a problem with our centrals or PICCS. Is the pharmacy diluting as far down as they can to decrease the viscocity? I don't know our dilution off the top of my head, but I believe it is the one in the neofax. We will put in a PICC for the 30 day treatment. What size is the PICC....I can see a problem if you are using a 1fr, but the 2fr should be fine.

[ScammRNC]

we use rifampin infrequently, but have never had any problems with it clotting off picc lines.

[Sweeper933]

we use rifampin infrequently, but have never had any problems with it clotting off picc lines.

same here

do your picc lines that are clotting off have fluid w/ heparin running through them continuously? when we are keeping central lines open just for antibiotics, we have fluid (usually d10 w/ lytes) running through them w/ 1unit heparin/ml. but i guess in the case of the rifampin, it would have to be d5w.