Really long commute to find work

I've only been licensed for a month, but I have applied to hundreds of jobs, and little has panned out. Certainly nothing in my desired areas of nursing. However, if I were to travel 3-4+ hours, there are positions in those areas that do not require experience, and I know some of these areas to have challenges filling positions. They don't pay as much as hospitals in my area, but experience is what I need in order to work at home (San Francisco Bay Area). I am looking at trying to land something that might have me away from home for a couple of back-to-back shifts per week, where I can stay overnight somewhere, and then head home for the rest of the week. I know that this will wear on my family (I'm married with a school-age child), but I feel like there are few other options in order to get into acute care, without full-on uprooting my whole family, something we both don't want to do and would be challenged in doing, since my husband's business and family (for whom we care) are here.

Is anyone else doing this sort of thing, staying away a couple of nights a week in order to work? How is it going for you? What are the pros and cons in your particular scenario (I know this will vary for everyone)?