Nope, nope, nope. I work PRN at the hospital I was at full-time for extra money. Not gonna lie, I absolutely dread the required one 12 hour shift/month. I love my job, my hours, my students, my co-workers, the autonomy.
I prefer the five days a week, mainly because I have kids. Working the 12's meant I wouldn't get home until they were already in bed, and if by some chance they were still awake, I didn't want to touch them with my MRSA, CDIFF, gross clothes. So now I get home before they do and I am there for homework and supper and baths and bedtime. Not to mention being off weekends, holidays, breaks...
I'm a nurse the the school, so I can't really speak to the type of position you will be in, sorry!
I also don't think it would be hard to get back into a bedside position, but I guess that depends on your location.