Patient going for an angiogram who is allergic to Iodine on our floor must be given 2 doses of Prednisone before and after the procedure. I looked up prednisone and under the label it says that this drug can be used to treat allergic reactions but I do not fully understand the pathophysiology. I know that Prednisone is a corticosteroid and that it decreases inflammation in the body. But I don't understand the relationship between giving this drug to stop anaphalytic reaction or skin reaction. Can someone break it down to me?