DutchgirlRN, ASN, RN 1 Article; 3,932 Posts Specializes in OB, M/S, HH, Medical Imaging RN. Has 33 years experience. Mar 20, 2008 mike rt why is multiple myeloma a contraindication for contrast.... any literature? thanks in advance.multiple myeloma is a progressive hematologic (blood) disease. it is cancer of the plasma cell which is a part of the immune system. if patient who has multiple myeloma are injected with contrast they could potentially go into renal failure. i questioned that when i first started doing medical imaging. i thought it meant someone who had had multiple skin cancers but no.