I worked as an independent contractor for a year in hospice nursing. I had my taxes done at H&R block and got a letter TWO years later stating that I owed the IRS over ONE THOUSAND DOLLARS. I did the estimated quarterly taxes the whole time I worked as an independent contractor to avoid just that very situation.
If you do use a tax pro, I recommend asking for their experience with independent contractors and asking for a few references from their independent contractor clients.
Here is a link to the Self-Employed Individual Tax Center from the IRS:
Self-Employed Individuals Tax Center
I thought it would be too complicated to deal with myself so I went to a tax pro (fat lot of good it did). You can make a lot of deductions on equipment and such but you must account for depreciation, blah, blah, blah. I didn't have the time or patience to do it myself, but kudos to you if you do.
Finally, keep all of your receipts and records as I read somewhere that independent contractors are especially targeted for audits.