You probably want to stay out of Harrisburg City itself. There are a lot of nice suburbs, including Chambers Hill (where we live), certain sections of Swatara & Lawnton, West Hanover Township, and you can always go "across the river" to Mechanicsburg, Camp Hill, or Lemoyne.
The price of housing depends on what township you settle in. For an older home with 3 bedrooms, 2 baths, AC, etc., you are looking at anywhere from $130K and up. You will pay more in Hershey or Mechanicsburg. There are many new home developments staring around $230K. Property taxes are fairly reasonable at anywhere from $1200 - $3500 per year, again depending on the township. To give you an idea.....our home is in a quiet community (Chambers Hill), our elementary school has 200 kids. Our home is 3,000 sq. ft. with A/C, 3 bedroom, 1 1/2 bath, privacy fence, full finished basement with spa room, H/W floors throughout, deck, additions to the kitchen & DR, 2 fireplaces built in 1964. We paid $159K in 2004. Similar houses in our neighborhood have went for $190K recently.
There are plenty of places to go, and no matter what area you decide to settle in, a grocery store & gas station is sure to be less than 5 min. away. Most areas have convienent access to the major highways. I love this area & we will definitely be retiring here.
As for nurses, there are 4 major hospitals within 20 minutes of each other. There are also many rehab facilities, freestanding psych units, nursing homes, etc. Never a shortage of nursing jobs
The realtor that helped us find this house was excellent. Let me know if you would like his name & phone #, he is with Remaxx & is very knowledgeable about locations. Good luck to you.