there is really nothing fun about neonatal sepsis. My poor daughter almost got an LP at 2 days old because they thought she had it although it turned out it was contaminated blood cultures. I would just say make an informational presentation.
My suggestion, remember what it is like to sit through a presentation where someone reads word for word a powerpoint slide... HORRIBLE
Be interactive, asking questions, showing pictures (of supplies, LP, ABX, etc) Get interesting statistics that have the "Wow I had no clue" factor
And then maybe at the end, because I do agree the subject is the farthest thing from fun that I can imagine, close with "Now that you have learned about Neonatal Sepsis and are utterly depressed here is something to cheer you up" and have a Nursing Comic or a really funny TOTALLY off topic picture to cheer everyone up.
Ugh! I don't understand why someone can't post a thread without another becoming personally offended. By "fun" the OP meant something that will keep her audience interested, not taking neonatal sepsis lightly, c'mon! *off soapbox*
I would say plan an activity to get the audience involved. Be sure to use lots of visuals and try to stray from just using a power point. Have actual hands on things to show. Create a handout for people to take with them with your major points on it. Good luck!