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getoverit 5,199 Views

Joined Dec 30, '07. Posts: 436 (51% Liked) Likes: 773

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  • Aug 29

    Quote from cfsleo812
    Can someone please break it down really simple, elementary my dear: what is cardiac preload, afterload? Feel free to give specific examples with drugs that affect each to make it crystal clear, thanks.
    Hey cfsleo812,
    So: really simple, elementary preload and afterload, huh? Good question.
    Basically, preload is stretch. The amount of volume being returned to the right side of the heart from systemic circulation. Afterload is squeeze. The amount of resistance the left side of the heart has to overcome in order to eject blood.
    Just look at the mechanism of action with different drugs to see what they do. e.g. a dilator will decrease, so the pressure comes down and the heart has less resistance to overcome, the catch is that it can also lead to less venous return, hypotension, ischemia. A pressor will increase, hopefully leading to better return to the heart. But it can also create too much resistance, which also can lead to problems.
    This is a very simplified definition, hope it helps. Sometimes the simplest things are the most useful.

  • Aug 6

    Quote from cfsleo812
    Can someone please break it down really simple, elementary my dear: what is cardiac preload, afterload? Feel free to give specific examples with drugs that affect each to make it crystal clear, thanks.
    Hey cfsleo812,
    So: really simple, elementary preload and afterload, huh? Good question.
    Basically, preload is stretch. The amount of volume being returned to the right side of the heart from systemic circulation. Afterload is squeeze. The amount of resistance the left side of the heart has to overcome in order to eject blood.
    Just look at the mechanism of action with different drugs to see what they do. e.g. a dilator will decrease, so the pressure comes down and the heart has less resistance to overcome, the catch is that it can also lead to less venous return, hypotension, ischemia. A pressor will increase, hopefully leading to better return to the heart. But it can also create too much resistance, which also can lead to problems.
    This is a very simplified definition, hope it helps. Sometimes the simplest things are the most useful.

  • May 3

    The insulin injection is just a hormone that stimulates glucose to cross the cell membrane and provokes the uptake of potassium as well. I believe it has something to do with the size of the molecule (macro-). The high potassium you saw in your patient was serum k+ so it needs to be forced back into the cells. Remember that if all our potassium was in the extracellular space it would be immeasurably high: 50-100x the normal value.
    Within 30-60 minutes the potassium should begin to shift back into the cells. The glucose is given to prevent iatrogenic hypoglycemia. IV calcium should be given if any acute EKG changes are noted and most of the literature I've read lately doesn't support the effectiveness of NaHCO3 very much (in fact, we don't use it much anymore).
    Recent AHA guidelines don't recommend giving a potassium-binder like Kayexelate anymore for emergent treatment of hyperkalemia. It forms a composite of resin and potassium which is excreted in feces, but takes at least 24 hours. Occasionally we give them all in conjunction with each other, to provide immediate and extended treatment.
    Of course one of the fastest and most reliable ways of correcting the k+ is hemodialysis. It's interesting to note that albuterol also displaces the potassium back into the cell and can be used to potentiate the effect of the insulin.

  • Feb 21

    I hear you, and all the posters who said you have to set limits and demand the respect you deserve are exactly right.
    We had a lady on the vent for 60+ days with pulmonary fibrosis, and every day you could tell what her family had looked up on WebMD the night before. Asking detailed, questions about vent setting trivia, acting angry the split second it seemed like she wasn't the center of attention at all times. Her husband yelled at one of my co-workers one afternoon about how "no one has been taking care of her". I went in the room and told him to google pressure ulcer when he got home and then ask himself how she had been laid up here for 2 months without having one....then see if he still thinks no one's been taking care of her.
    He must have done it because the next day he apologized and that was the end of them acting like that. Miraculously, without us ever taking care of her, she managed to survive her admission and went back home.

  • Dec 23 '16

    strange aneurysm around the aortic root, closest surgeon who would accept the case was 1000+ miles away (Baylor). He exsanguinated right in front of us as we were loading him into the plane, gone in less than 3 sec.

    young child needed a heart transplant (and successfully received it). his cardiac silhouette filled the cxr. he was so fatigued that his lips would turn blue and his hr increased 200+ just lifting his arm for a bp cuff or sat probe.

    and flyingscot, I've also coded someone and ran into them a few days later in the grocery store holding a case of budweiser and carton of marlboros. nothing like getting a new lease on life!!



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