Diabetes meds driving me crazy!
- 0Mar 25, '13 by dayanaraI always get mixed up with the onset and peak of the insulins and cannot see the bigger picture regarding oral meds.
Any suggestions on how to learn these better? Thanks:-)
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- 2Mar 26, '13 by Esme12 Senior ModeratorAction of Commonly Prescribed Insulin......IOH types of insulin; chart of duration and action of insulin
NameTypeOnset(1)Peak(1)Duration(1)Humalog (Lispro)Rapid5-15 minutes30-75 minutes2-3 hoursApidra (glulisine)Rapid5-15 minutes30-75 minutes2-4 hoursNovolog (Aspart)Rapid10-20 minutes1-3 hours3-5 hoursRegular (R)Short-Acting30 minutes2-5 hours5-8 hoursNPH (N)Intermediate1-3 hours6-12 hours16-24 hoursLente (L)Intermediate1-3 hours6-12 hours16-24 hoursUltralente (U)Long-Acting3-5 hours8-14 hours18 hoursGlargine LantusVery Long-Acting1 hourEvenly for 24 hours24-28 hoursNPH & Regular Mixed in either
50/50 mix, or
70/30 mixPremixed30-60 minutes2-12 hoursup to 18 hours
- 0Mar 26, '13 by Floridatrail2006In my experience, I commited to memory 3-5 of the most common insulins. For instance, humalog, novolog, regular, nph, and lantus. These five are very common. If you come acrossed another type in your studies or clinicals, look em up (as usual).
However, I too have had issues remembering insulin onset, peak, and duration. You can draw a graph for each one. Or, the main three. Novolog, regular, and lantus. That is what I did and I'm able to reproduce it to this day and not having drawn it in months. Try it.
- 3Mar 26, '13 by eva123Now that you have some good advice on the insulins here's some info on oral antidiabetics:
*Alpha-Glucosidase Inhibitors (Acarbose, Miglitol) act locally in GI tract to inhibit Alpha-glucosidase which is responsible for carb breakdown, because of it's mechanism of action it does not cause hypoglycemia.
*Biguanides (Metformin) works by multiple mechanisms. It reduces gluconeogenesis, decreases intestinal reabsorption of glucose, increases cellular uptake of glucose, and increases excretion of glucose. It also does not cause hypoglycemia.
*Incretin enhancers (Sitagliptan/Januvia) Inhibits DPP-4 from breaking down incretins, increased levels of incretins lowers blood glucose because incretins respond to glucose load and are responsible for 60% of insulin release. These can cause hypoglycemia.
*Meglitinides (Prandin) Stimulate insulin release from pancreatic beta-cells. These can cause hypoglycemia.
*Sulfonylureas (Glyburide, Glipizide) stimulate release of insulin from pancreatic beta cells and increase sensitivity of peripheral tissues to insulin. These can cause hypoglycemia.
*Thiazolidinedione aka TZDs (Avandia, Actose) increase cellular sensitivity to insulin and decrease gluconeogenesis by liver. These can cause hypoglycemia.
*Antihypoglycemic Agent (Glucogon/Gluca Gen) increases glycogenolysis, stimulates uptake of amino acids, increases gluconeogenesis, and promotes lipolysis.
You can find all of this in your drug book and much more information, but this should provide a brief overview. I pulled this information from Davis's Drug Guide and my teachers. Hope it helps.