INR increasing...without anticoagulation? - page 2

I've had several pts with multiple different diagnoses and admitting problems whose INR continued to increase daily despite holding Lovenox, Coumadin, etc. One pt had daily INRs of 6.3, then 7.1,... Read More

  1. by   ghillbert
    If INR is 13 despite multiple doses of Vitamin K, it's time to give some FFP and get it down. That's a cerebral hemorrhage waiting to happen!
  2. by   turnforthenurse
    Tylenol can also interfere with Coumadin metabolism and in turn affects your liver which can further interfere with metabolism...I had a patient with an INR of 9.9. Took a lot of Tylenol. That patient got some bags of FFP and INR stabilized
  3. by   joyfulmission
    It may be due to HIT (Heparin induced thrombocytopenia)...just a thought
  4. by   ozarkmomma
    heparin induced thrombcytopenia... liver failure, sepsis
  5. by   sharifi9879
    regarding to the wide drug interaction between Comadin and many drugs, please consider following items.
    Independent risk factors for an increased risk of INR above 6.0 were:
    • advanced malignancy,
    • newly started medicines with the potential to interfere with warfarin metabolism
    • taking more warfarin than was prescribed
    • a decreased consumption of foods rich in vitamin K
    • acute diarrheal illness

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