INR increasing...without anticoagulation? - page 2
I've had several pts with multiple different diagnoses and admitting problems whose INR continued to increase daily despite holding Lovenox, Coumadin, etc. One pt had daily INRs of 6.3, then 7.1, then 7.4. All the while holding... Read More
- 0Jul 1, '12 by nerdtonurse?Also, if the patient has cancer, they usually have low albumin (either d/t the disease process or malnutrition); low albumin can affect protein binding, making more warfarin stay in the system longer. I know seems particularly tricky to anticoag someone with GI CA and liver CA who need something due to afib, artificial valves, etc. Lovenox works better than warfarin in those cases, in my experience.
- 0Aug 7, '12 by sharifi9879regarding to the wide drug interaction between Comadin and many drugs, please consider following items.
Independent risk factors for an increased risk of INR above 6.0 were:
- advanced malignancy,
- newly started medicines with the potential to interfere with warfarin metabolism
- taking more warfarin than was prescribed
- a decreased consumption of foods rich in vitamin K
- acute diarrheal illness