INR increasing...without anticoagulation? - page 2
I've had several pts with multiple different diagnoses and admitting problems whose INR continued to increase daily despite holding Lovenox, Coumadin, etc. One pt had daily INRs of 6.3, then 7.1,... Read More
Jul 13, '12If INR is 13 despite multiple doses of Vitamin K, it's time to give some FFP and get it down. That's a cerebral hemorrhage waiting to happen!
Jul 18, '12Tylenol can also interfere with Coumadin metabolism and in turn affects your liver which can further interfere with metabolism...I had a patient with an INR of 9.9. Took a lot of Tylenol. That patient got some bags of FFP and INR stabilized
Aug 7, '12regarding to the wide drug interaction between Comadin and many drugs, please consider following items.
Independent risk factors for an increased risk of INR above 6.0 were:
- advanced malignancy,
- newly started medicines with the potential to interfere with warfarin metabolism
- taking more warfarin than was prescribed
- a decreased consumption of foods rich in vitamin K
- acute diarrheal illness