Tomskatt, I did travel nursing in S. Carolina for 4r yrs, and would go back in a heartbeat. But not to live! School system wasn't the best...so I homeschooled my daughter will there. And the schools even helped me with getting started, and referred me to a homeschool network.
Hilton Head I can only comment on the fact that the area is beautiful, and I always felt safe while working in the area. But expensive...even Mickey D's!!! But they have a great hospital, and I have yet to hear a traveler complain about it.
Savanah was a whole other story though. I though about relocationg there, and changed my mind.
You could always take a travel assignment there, and see how you like it.
Good luck whatever you decide