I had to reply to this old post because after working 4 13-14 hours shifts on a short-staffed rehab unit (knowing I had 2 more shifts to go), my thighs were a hot mess. By the end of my 4th shift, I could barely walk. I had two open sores on my thighs.... One sore was BLEEDING. I searched the net for something to help, as I was on the verge of crying... Or calling in the next day. Lol. Here is what I did. I took ibuprofen, applied hydrocortisone cream, and iced my thighs that night. Next morning, I took a different route and applied corn starch and wore a pair of spandex shorts. And I survived with minimal pain the next couple of shift (walking approximately 5 miles per shift caring for 26 people..when I typically only care of 13 ðŸ˜µ). Good luck desperate thigh chafing nurses!